Department of Biomedical Engineering, University of Texas at Austin, Austin, 78712, TX, USA.
Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, 78712, TX, USA.
Adv Healthc Mater. 2017 Nov;6(22). doi: 10.1002/adhm.201700556. Epub 2017 Sep 25.
Mesenchymal stem cells (MSCs) are an appealing potential therapy for vascular diseases; however, many challenges remain in their clinical translation. While the use of biochemical, pharmacological, and substrate-mediated treatments to condition MSCs has been subjected to intense investigation, there has been far less exploration of using these treatments in combination with applied mechanical force for conditioning MSCs toward vascular phenotypes. This review summarizes the current understanding of the use of applied mechanical forces to differentiate MSCs into vascular cells and enhance their therapeutic potential for cardiovascular disease. First recent work on the use of material-based mechanical cues for differentiation of MSCs into vascular and cardiovascular phenotypes is examined. Then a summary of the studies using mechanical stretch or shear stress in combination with biochemical treatments to enhance vascular phenotypes in MSCs is presented.
间充质干细胞（MSCs）是一种有吸引力的潜在血管疾病治疗方法；然而，它们在临床转化中仍存在许多挑战。虽然使用生化、药理学和基质介导的治疗方法来调节 MSC 已经受到了广泛的研究，但对于将这些治疗方法与施加的机械力结合起来用于调节 MSC 向血管表型的研究却少得多。这篇综述总结了目前利用施加的机械力将 MSC 分化为血管细胞并增强其治疗心血管疾病的潜力的研究进展。首先，研究了利用基于材料的机械线索将 MSC 分化为血管和心血管表型的最新工作。然后，介绍了使用机械拉伸或切变应力与生化处理相结合来增强 MSC 中血管表型的研究。
