Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
University of Chinese Academy of Sciences , Beijing 100049, China.
ACS Appl Mater Interfaces. 2017 Oct 18;9(41):35539-35547. doi: 10.1021/acsami.7b08348. Epub 2017 Oct 6.
Chemotherapy as a conventional cancer treatment suffers from critical systemic side effects, which is generally considered as the consequence of reactive oxygen species (ROS). Fullerenes have been widely studied for their excellent performance in radicals scavenging. In the present study, we report a solid-liquid reaction to synthesize fullerenols and their application as ROS scavengers in chemotherapy protection. The solid-liquid reaction is carried out without catalyst and suitable for mass production. The novel [60]/[70] fullerenols show a high stability in water, and the [70] fullerenols (C-OH) exhibit radical scavenging capability superior to that of [60] fullerenols (C-OH) in chemotherapy protection. The mouse model for single and reduplicative chemotherapy-induced liver injury demonstrates their protective effects in the chemotherapeutic process, which is confirmed by histopathological examinations and hematological index. The increase of the hepatic l-glutathione (GSH) level and downregulated expression of the cytochrome P-450 2E1 (CYP2E1) give the possible mechanism associated with the impact of fullerenols on the metabolism of doxorubicin. The novel fullerenols may be promising protective agents to satisfy the demand for future clinical chemotherapy.
化疗作为一种传统的癌症治疗方法，存在严重的全身副作用，这通常被认为是活性氧（ROS）的后果。富勒烯因其在清除自由基方面的优异性能而得到广泛研究。在本研究中，我们报告了一种固-液反应来合成富勒醇及其在化疗保护中作为 ROS 清除剂的应用。该固-液反应无需催化剂，适合大规模生产。新型 [60]/[70] 富勒醇在水中具有很高的稳定性，[70] 富勒醇（C-OH）在化疗保护中表现出比 [60] 富勒醇（C-OH）更强的自由基清除能力。单次和重复化疗诱导的肝损伤小鼠模型证明了它们在化疗过程中的保护作用，这通过组织病理学检查和血液学指标得到了证实。肝 l-谷胱甘肽（GSH）水平的升高和细胞色素 P-450 2E1（CYP2E1）表达下调给出了与富勒醇对多柔比星代谢影响相关的可能机制。新型富勒醇可能是有前途的保护剂，以满足未来临床化疗的需求。
