Rajakumar G, Chiu P, Chiu S, Johnson R L, Mishra R K
Department of Psychiatry, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Peptides. 1987 Nov-Dec;8(6):997-1002. doi: 10.1016/0196-9781(87)90127-6.
Animal behavioral and neurochemical studies implicate dopaminergic systems in the neurological sequelae induced by estrogen. In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17 beta-estradiol, antagonized significantly the estrogen-induced increase in the density of dopamine D-2 receptor both in the striatum and the mesolimbic area of male rat brain. The current findings have implications for the prophylactic and therapeutic potential for MIF-1 in extrapyramidal motor disorders caused by estrogen imbalance in humans.
动物行为学和神经化学研究表明，多巴胺能系统与雌激素诱导的神经后遗症有关。在本研究中，我们首次证明，促黑素细胞激素释放抑制因子-1（MIF-1），一种与经典多巴胺激动剂无关的神经肽，在17β-雌二醇给药前、给药时和给药后给予，能显著拮抗雌激素诱导的雄性大鼠脑纹状体和中脑边缘区多巴胺D-2受体密度的增加。目前的研究结果提示了MIF-1在人类因雌激素失衡引起的锥体外系运动障碍中的预防和治疗潜力。
