RCSI Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre Beaumont Hospital, Dublin 9, Ireland; Institute of Food & Health, UCD School of Agriculture and Food Science, University College Dublin, Dublin 4, Ireland.
Institute of Food & Health, UCD School of Agriculture and Food Science, University College Dublin, Dublin 4, Ireland.
Schizophr Res. 2018 May;195:32-50. doi: 10.1016/j.schres.2017.09.021. Epub 2017 Sep 22.
Current diagnosis of schizophrenia relies exclusively on the potentially subjective interpretation of clinical symptoms and social functioning as more objective biological measurement and medical diagnostic tests are not presently available. The use of metabolomics in the discovery of disease biomarkers has grown in recent years. Metabolomic methods could aid in the discovery of diagnostic biomarkers of schizophrenia. This systematic review focuses on biofluid metabolites associated with schizophrenia. A systematic search of Web of Science and Ovid Medline databases was conducted and 63 studies investigating metabolite biomarkers of schizophrenia were included. A review of these studies revealed several potential metabolite signatures of schizophrenia including reduced levels of essential polyunsaturated fatty acids (EPUFAs), vitamin E and creatinine; and elevated levels of lipid peroxidation metabolites and glutamate. Further research is needed to validate these biomarkers and would benefit from large cohort studies and more homogeneous and well-defined subject groups.
目前对精神分裂症的诊断仅依赖于对临床症状和社会功能的潜在主观解释，因为目前尚无更客观的生物学测量和医学诊断测试。近年来，代谢组学在发现疾病生物标志物方面的应用不断增加。代谢组学方法可以帮助发现精神分裂症的诊断生物标志物。本系统评价重点关注与精神分裂症相关的生物流体代谢物。对 Web of Science 和 Ovid Medline 数据库进行了系统搜索，纳入了 63 项研究精神分裂症代谢物生物标志物的研究。对这些研究的回顾揭示了一些潜在的精神分裂症代谢物特征，包括必需多不饱和脂肪酸 (EPUFAs)、维生素 E 和肌酸水平降低，脂质过氧化代谢物和谷氨酸水平升高。需要进一步研究来验证这些生物标志物，并且从大型队列研究和更同质和明确界定的研究对象组中获益。
