Shalev A, Hermesh H, Munitz H
Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tikva, Israel.
Acta Psychiatr Scand. 1987 Dec;76(6):715-8. doi: 10.1111/j.1600-0447.1987.tb02944.x.
Several neuroleptics recurrently failed to ameliorate psychosis in three schizophrenic patients. Failures were caused by recurrent intractable akathisia, unresponsive to diazepam and trihexyphenidyl. Lacking this extrapyramidal side effect, lithium carbonate was tried and proved an effective antipsychotic. It is suggested that in schizophrenic psychosis lithium is a rational therapeutic option in cases of neuroleptic intolerance and failures due to akathisia.
几种抗精神病药物反复治疗均未能改善3例精神分裂症患者的精神病症状。治疗失败是由反复出现的难治性静坐不能引起的，地西泮和苯海索对此均无反应。由于碳酸锂没有这种锥体外系副作用，因此对其进行了试验，结果证明它是一种有效的抗精神病药物。有人提出，在精神分裂症性精神病中，对于抗精神病药物不耐受以及因静坐不能导致治疗失败的病例，锂盐是一种合理的治疗选择。
