Soni S D, Tench D, Routledge R C
Department of Psychological Medicine, University of Manchester School of Medicine, Hope Hospital, Salford.
Br J Psychiatry. 1993 Nov;163:669-72. doi: 10.1192/bjp.163.5.669.
Twenty-two schizophrenic patients (DSM-III-R criteria) with clinically significant akathisia were matched with 22 schizophrenic patients without akathisia on the following variables: age, sex, diagnosis, duration of illness, and current treatment. Both groups were assessed using a variety of clinical rating scales and several parameters of serum iron status. The akathisic patients showed greater severity of clinical psychopathology, particularly positive symptoms, and an excess of extrapyramidal side-effects. We were unable to confirm any association between low serum iron and neuroleptic-induced akathisia in our sample of community-based patients.
22名符合临床显著静坐不能标准（依据《精神疾病诊断与统计手册第三版修订本》标准）的精神分裂症患者，与22名无静坐不能的精神分裂症患者在以下变量上进行匹配：年龄、性别、诊断、病程及当前治疗情况。两组均使用多种临床评定量表及血清铁状态的多个参数进行评估。有静坐不能的患者临床精神病理学症状更严重，尤其是阳性症状，且锥体外系副作用更多。在我们这个社区患者样本中，未能证实低血清铁与抗精神病药物所致静坐不能之间存在任何关联。
