Tsang C, Boulton C, Burgon V, Johansen A, Wakeman R, Cromwell D A
London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London WC1H 9SH, UK and Honorary Lecturer, The Royal College of Surgeons of England, 35-43 Lincoln's Inn Fields, London WC2A 3PE, UK
Clinical Effectiveness and Evaluation Unit, Royal College of Physicians, 11 St Andrews Place, London NW1 4LE, UK.
Bone Joint Res. 2017 Sep;6(9):550-556. doi: 10.1302/2046-3758.69.BJR-2017-0020.R1.
The National Hip Fracture Database (NHFD) publishes hospital-level risk-adjusted mortality rates following hip fracture surgery in England, Wales and Northern Ireland. The performance of the risk model used by the NHFD was compared with the widely-used Nottingham Hip Fracture Score.
Data from 94 hospitals on patients aged 60 to 110 who had hip fracture surgery between May 2013 and July 2013 were analysed. Data were linked to the Office for National Statistics (ONS) death register to calculate the 30-day mortality rate. Risk of death was predicted for each patient using the NHFD and Nottingham models in a development dataset using logistic regression to define the models' coefficients. This was followed by testing the performance of these refined models in a second validation dataset.
The 30-day mortality rate was 5.36% in the validation dataset (n = 3861), slightly lower than the 6.40% in the development dataset (n = 4044). The NHFD and Nottingham models showed a slightly lower discrimination in the validation dataset compared with the development dataset, but both still displayed moderate discriminative power (c-statistic for NHFD = 0.71, 95% confidence interval (CI) 0.67 to 0.74; Nottingham model = 0.70, 95% CI 0.68 to 0.75). Both models defined similar ranges of predicted mortality risk (1% to 18%) in assessment of calibration.
Both models have limitations in predicting mortality for individual patients after hip fracture surgery, but the NHFD risk adjustment model performed as well as the widely-used Nottingham prognostic tool and is therefore a reasonable alternative for risk adjustment in the United Kingdom hip fracture population.: 2017;6:550-556.
国家髋部骨折数据库(NHFD)公布了英格兰、威尔士和北爱尔兰髋部骨折手术后医院层面经风险调整的死亡率。将NHFD所使用的风险模型的性能与广泛使用的诺丁汉髋部骨折评分进行了比较。
分析了94家医院在2013年5月至2013年7月期间对60至110岁髋部骨折手术患者的数据。数据与国家统计局(ONS)死亡登记册相链接以计算30天死亡率。在一个开发数据集中,使用逻辑回归来定义模型系数,通过NHFD和诺丁汉模型对每位患者的死亡风险进行预测。随后在第二个验证数据集中测试这些优化模型的性能。
验证数据集中(n = 3861)的30天死亡率为5.36%,略低于开发数据集中(n = 4044)的6.40%。与开发数据集相比,NHFD和诺丁汉模型在验证数据集中的辨别力略低,但两者仍显示出中等辨别力(NHFD的c统计量 = 0.71,95%置信区间(CI)为0.67至0.74;诺丁汉模型 = 0.70,95% CI为0.68至0.75)。在评估校准方面,两个模型定义的预测死亡风险范围相似(1%至18%)。
两个模型在预测髋部骨折手术后个体患者的死亡率方面都存在局限性,但NHFD风险调整模型的表现与广泛使用的诺丁汉预后工具相当,因此是英国髋部骨折人群风险调整的合理替代方案。: 2017;6:550 - 556。