Chu Qingpo, Liang Tingting, Fu Lingling, Li Huizhi, Zhou Bo
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, People's Republic of China.
J Genet. 2017 Sep;96(4):707-715. doi: 10.1007/s12041-017-0826-3.
Aggression is a heritable trait and genetically related to neurotransmitter-related genes. Behavioural characteristics of some pig breeds are different. To compare the genetic differences between breeds, backtest and aggressive behaviour assessments, and genotyped using Sequenom iPLEX platform were performed in 50 Chinese indigenous Mi pigs and 100 landrace-large white (LLW) cross pigs with 32 SNPs localized in 11 neurotransmitter-related genes. The genetic polymorphisms of 26 SNPs had notable differences (P < 0.05) between Mi and LLW. The most frequent haplotypes were different in DBH, HTR2A, GAD1, HTR2B,MAOA and MAOB genes between Mi and LLW. The mean of backtest scores was significantly lower (P < 0.001) for Mi than LLW pigs. Skin lesion scores were greater (P < 0.01) in LLW pigs than Mi pigs. In this study, we have confirmed that Chinese Mi pigs are less active and less aggressive than European LLW pigs, and the genetic polymorphisms of neurotransmitter-related genes, which have been proved previously associated with aggressive behaviour, have considerable differences between Mi and LLW pigs.
攻击性是一种可遗传的性状，与神经递质相关基因存在遗传关联。一些猪品种的行为特征有所不同。为了比较不同品种之间的遗传差异，对50头中国本土米猪和100头长白-大白（LLW）杂交猪进行了回测和攻击行为评估，并使用Sequenom iPLEX平台进行基因分型，涉及11个神经递质相关基因中的32个单核苷酸多态性（SNP）。米猪和LLW猪之间26个SNP的基因多态性存在显著差异（P < 0.05）。米猪和LLW猪在DBH、HTR2A、GAD1、HTR2B、MAOA和MAOB基因中的最常见单倍型有所不同。米猪的回测分数平均值显著低于LLW猪（P < 0.001）。LLW猪的皮肤损伤分数高于米猪（P < 0.01）。在本研究中，我们证实中国米猪比欧洲LLW猪活跃度更低、攻击性更弱，并且先前已证明与攻击行为相关的神经递质相关基因的基因多态性在米猪和LLW猪之间存在相当大的差异。
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