Piao Longzhu, Mukherjee Sumit, Chang Qing, Xie Xiujie, Li Hong, Castellanos Mario R, Banerjee Probal, Iqbal Hassan, Ivancic Ryan, Wang Xueqian, Teknos Theodoros N, Pan Quintin
Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Medical Center, Columbus, Ohio, USA.
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
Oncotarget. 2016 Jul 16;8(36):60025-60035. doi: 10.18632/oncotarget.10620. eCollection 2017 Sep 1.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide with about 600,000 new cases diagnosed in the last year. The incidence of human papillomavirus-positive head and neck squamous cell carcinoma (HPV-positive HNSCC) has rapidly increased over the past 30 years prompting the suggestion that an epidemic may be on the horizon. Therefore, there is a clinical need to develop alternate therapeutic strategies to manage the growing number of HPV-positive HNSCC patients. TriCurin is a composition of three food-derived polyphenols in unique stoichiometric proportions consisting of curcumin from the spice turmeric, resveratrol from red grapes, and epicatechin gallate from green tea. Cell viability, clonogenic survival, and tumorsphere formation were inhibited and significant apoptosis was induced by TriCurin in UMSCC47 and UPCI:SCC090 HPV-positive HNSCC cells. Moreover, TriCurin decreased HPV16E6 and HPV16E7 and increased p53 levels. In a pre-clinical animal model of HPV-positive HNSCC, intra-tumoral injection of TriCurin significantly inhibited tumor growth by 85.5% compared to vehicle group ( < 0.05, = 7). Our results demonstrate that TriCurin is a potent anti-tumor agent for HPV-positive HNSCC. Further development of TriCurin as a novel anti-cancer therapeutic to manage the HPV-positive HNSCC population is warranted.
头颈部鳞状细胞癌（HNSCC）是全球第六大常见癌症，去年约有60万新病例被诊断出来。在过去30年中，人乳头瘤病毒阳性头颈部鳞状细胞癌（HPV阳性HNSCC）的发病率迅速上升，这引发了一种可能即将出现流行的说法。因此，临床上需要开发替代治疗策略来应对越来越多的HPV阳性HNSCC患者。TriCurin是一种由三种食物来源的多酚按独特化学计量比例组成的化合物，包括姜黄香料中的姜黄素、红葡萄中的白藜芦醇和绿茶中的表没食子儿茶素没食子酸酯。TriCurin在UMSCC47和UPCI:SCC090 HPV阳性HNSCC细胞中抑制了细胞活力、克隆形成存活和肿瘤球形成，并诱导了显著的细胞凋亡。此外，TriCurin降低了HPV16E6和HPV16E7的水平，并提高了p53水平。在HPV阳性HNSCC的临床前动物模型中，与载体组相比，瘤内注射TriCurin显著抑制肿瘤生长85.5%（<0.05，n=7）。我们的结果表明，TriCurin是一种针对HPV阳性HNSCC的有效抗肿瘤药物。有必要进一步开发TriCurin作为一种新型抗癌疗法来治疗HPV阳性HNSCC人群。
