Division of Pediatric Oncology/Hematology, Meyer University Children's Hospital, 50139 Florence, Italy.
Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Int J Mol Sci. 2020 Mar 12;21(6):1936. doi: 10.3390/ijms21061936.
In recent years, epidemiological studies have shown that food is a very powerful means for maintaining a state of well-being and for health prevention. Many degenerative, autoimmune and neoplastic diseases are related to nutrition and the nutrient-organism interaction could define the balance between health and disease. Nutrients and dietary components influence epigenetic phenomena and modify drugs response; therefore, these food-host interactions can influence the individual predisposition to disease and its potential therapeutic response. Do nutraceuticals have positive or negative effects during chemotherapy? The use of nutraceutical supplements in cancer patients is a controversial debate without a definitive conclusion to date. During cancer treatment, patients take nutraceuticals to alleviate drug toxicity and improve long-term results. Some nutraceuticals may potentiate the effect of cytotoxic chemotherapy by inducing cell growth arrest, cell differentiation, and alteration of the redox state of cells, but in some cases, high levels of them may interfere with the effectiveness of chemotherapy, making cancer cells less reactive to chemotherapy. In this review, we highlighted the emerging opinions and data on the pros and cons on the use of nutraceutical supplements during chemotherapy.
近年来，流行病学研究表明，食物是维持健康状态和预防疾病的非常有力的手段。许多退行性、自身免疫性和肿瘤疾病都与营养有关，营养与机体的相互作用可以定义健康与疾病之间的平衡。营养素和膳食成分影响表观遗传现象，并改变药物反应；因此，这些食物-宿主的相互作用可以影响个体对疾病的易感性及其潜在的治疗反应。在化疗期间，营养保健品有积极或消极的影响吗？在癌症患者中使用营养保健品是一个有争议的话题，目前尚无明确结论。在癌症治疗过程中，患者服用营养保健品以减轻药物毒性并改善长期结果。一些营养保健品可能通过诱导细胞生长停滞、细胞分化和改变细胞的氧化还原状态来增强细胞毒性化疗的效果，但在某些情况下，它们的高水平可能会干扰化疗的效果，使癌细胞对化疗的反应性降低。在这篇综述中，我们强调了关于在化疗期间使用营养保健品的利弊的新观点和数据。
