冠心病患者心外膜和皮下脂肪组织的脂肪因子和细胞因子谱
Adipokine and Cytokine Profiles of Epicardial and Subcutaneous Adipose Tissue in Patients with Coronary Heart Disease.
作者信息
Gruzdeva O V, Akbasheva O E, Dyleva Yu A, Antonova L V, Matveeva V G, Uchasova E G, Fanaskova E V, Karetnikova V N, Ivanov S V, Barbarash O L
机构信息
Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia.
Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
出版信息
Bull Exp Biol Med. 2017 Sep;163(5):608-611. doi: 10.1007/s10517-017-3860-5. Epub 2017 Sep 25.
The content of adipokines, pro- and anti-inflammatory cytokines were studied in adipocytes isolated from epicardial and subcutaneous adipose tissue of 24 coronary heart disease patients. The content of leptin and soluble leptin receptor in adipocytes of epicardial adipose tissue was higher by 28.6 and 56.9% and the level of adiponectin was lower by 33% than in adipocytes of the subcutaneous fat. In culture of epicardial adipocytes, the levels of proinflammatory cytokines TNF-α and IL-1 were higher. Subcutaneous adipose tissue adipocytes were characterized by higher levels of anti-inflammatory cytokines IL-10 and FGF-β. In epicardial adipocytes of coronary heart disease patients, the concentrations of leptin, TNF-α, and IL-1 were higher, while the levels of defense regulatory molecules (adiponectin, IL-10, and FGF-β) were lower than in subcutaneous adipocytes.
对24例冠心病患者的心外膜和皮下脂肪组织分离出的脂肪细胞中脂肪因子、促炎和抗炎细胞因子的含量进行了研究。心外膜脂肪组织脂肪细胞中的瘦素和可溶性瘦素受体含量分别比皮下脂肪细胞高28.6%和56.9%，脂联素水平比皮下脂肪细胞低33%。在心外膜脂肪细胞培养中，促炎细胞因子TNF-α和IL-1的水平较高。皮下脂肪组织脂肪细胞的特点是抗炎细胞因子IL-10和FGF-β水平较高。冠心病患者的心外膜脂肪细胞中，瘦素、TNF-α和IL-1的浓度较高，而防御调节分子（脂联素、IL-10和FGF-β）的水平低于皮下脂肪细胞。
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