Rökenes H K, Andersson B, Rundcrantz H
Ear, Nose and Throat Department, Central Hospital, Skövde, Sweden.
Clin Allergy. 1988 Jan;18(1):63-9. doi: 10.1111/j.1365-2222.1988.tb02844.x.
Terfenadine (60 mg b.i.d.) was compared with placebo in a randomized, double-blind, cross-over study in twenty-three patients with birch pollen allergy. The patients were treated during two 7-day periods separated by a 2-week wash-out period during a season free from birch pollen. Nasal provocations with birch pollen extracts were made at study entry and after each treatment period. Blockage (rhinomanometry), secretion (weight) and sneezings (number) were compared between treatments. The results showed a significant inhibitory effect of terfenadine on secretion and sneezing, but no significant difference between treatments with regard to blockage. Terfenadine showed no signs of sedative properties or inhibition of salivation.
在一项针对23名桦树花粉过敏患者的随机、双盲、交叉研究中，将特非那定（每日两次，每次60毫克）与安慰剂进行了比较。在没有桦树花粉的季节，患者接受两个为期7天的治疗期，中间间隔2周的洗脱期。在研究开始时以及每个治疗期结束后，用桦树花粉提取物进行鼻腔激发试验。比较各治疗组之间的鼻阻塞（鼻阻力测量法）、分泌物（重量）和打喷嚏次数。结果显示，特非那定对分泌物和打喷嚏有显著抑制作用，但在鼻阻塞方面各治疗组之间无显著差异。特非那定没有表现出镇静特性或抑制唾液分泌的迹象。
