Lurie A, Saudubray F, Eychenne J L, Venot A, de Lauture D, Dessanges J F, Lockhart A, Strauch G
Eclimed, Institute de Recherche Thérapeutique, Hôpital Universitaire Cochin, Paris.
Eur J Clin Pharmacol. 1992;42(2):213-6. doi: 10.1007/BF00278487.
The effect of azelastine 2 mg b.d. p.o. for 10 days on grass pollen-induced nasal responses in 16 patients with grass pollen allergic rhinitis has been assessed. The study was a double blind, randomized, placebo controlled, crossover trial, with a 10-14 day wash-out period. Patients were challenged with grass pollen before and after placebo and azelastine. The response was assessed by measurement of nasal resistance using active posterior rhinomanometry, by weighing nasal secretions, and by counting sneezes. The sensation of nasal obstruction was assessed with a visual analogue scale. After measurement of baseline total nasal resistance, doubling doses of allergen were sprayed into both nostrils at 15 min intervals until the nasal resistance was doubled. Cumulative doses of allergen that doubled prechallenge nasal resistance, numbers of sneezes and the amounts of nasal secretions were similar before azelastine as well as before and after placebo (cumulative dose, mean, (microgram): 2.3, 4.2 and 2.1 respectively, N.S.). After azelastine, the cumulative dose of allergen was increased (7.3 micrograms), and nasal secretions and the number of sneezes were decreased. The visual analogue scores were similar before and after azelastine as well as before and after the placebo. It is concluded that azelastine reduced the allergen-induced nasal responses.
已评估了16例草花粉过敏性鼻炎患者口服氮卓斯汀2毫克、每日两次、共10天对草花粉诱发的鼻部反应的影响。该研究为双盲、随机、安慰剂对照、交叉试验，洗脱期为10 - 14天。患者在服用安慰剂和氮卓斯汀前后均接受草花粉激发试验。通过使用主动后鼻测压法测量鼻阻力、称量鼻分泌物以及计数喷嚏来评估反应。用视觉模拟量表评估鼻阻塞的感觉。在测量基线总鼻阻力后，每隔15分钟向双侧鼻孔喷洒双倍剂量的变应原，直至鼻阻力加倍。在服用氮卓斯汀之前以及服用安慰剂之前和之后，使激发前鼻阻力加倍的变应原累积剂量、喷嚏次数和鼻分泌物量相似（累积剂量，平均值，（微克）：分别为2.3、4.2和2.1，无显著差异）。服用氮卓斯汀后，变应原累积剂量增加（7.3微克），鼻分泌物和喷嚏次数减少。视觉模拟评分在服用氮卓斯汀前后以及服用安慰剂前后相似。结论是氮卓斯汀可减轻变应原诱发的鼻部反应。
