Dear J W, Scadding G K, Foreman J C
Department of Pharmacology, University College London.
Br J Pharmacol. 1995 Sep;116(2):1720-2. doi: 10.1111/j.1476-5381.1995.tb16653.x.
In non-allergic subjects, histamine induced a reduction of minimal nasal cross-sectional area (Amin) and an increase in albumin release into nasal lavage. The effect of histamine on albumin release was inhibited by pretreatment with NG-nitro-L-arginine methyl ester (L-NAME), 1 mumol but not by D-NAME, 1 mumol. L-NAME, 1 and 10 mumol, did not inhibit the histamine-induced reduction of Amin. In subjects allergic to grass pollen, antigen challenge induced a reduction in Amin that was not changed by pretreatment with L-NAME, and an increase in albumin release that was inhibited by L-NAME, 1 mumol. The data support a role for nitric oxide in mediating plasma extravasation in the nose induced by antigen challenge or histamine.
在非过敏受试者中，组胺可导致最小鼻腔横截面积（Amin）减小，且鼻腔灌洗液中白蛋白释放增加。用1 μmol的NG-硝基-L-精氨酸甲酯（L-NAME）预处理可抑制组胺对白蛋白释放的作用，但1 μmol的D-NAME则无此作用。1 μmol和10 μmol的L-NAME均未抑制组胺诱导的Amin减小。在对草花粉过敏的受试者中，抗原激发可导致Amin减小，而L-NAME预处理对此无影响；同时抗原激发可使白蛋白释放增加，而1 μmol的L-NAME可抑制此作用。这些数据支持一氧化氮在介导抗原激发或组胺诱导的鼻腔血浆外渗中起作用。
