修复小脑的意外助力。 - Suppr

Unexpected help to repair the cerebellum.

作者信息

Jaeger Baptiste N, Jessberger Sebastian

机构信息

Laboratory of Neural Plasticity, Faculty of Medicine and Science, Brain Research Institute, University of Zurich, Zurich, Switzerland.

出版信息

Nat Neurosci. 2017 Sep 26;20(10):1319-1321. doi: 10.1038/nn.4640.

DOI:10.1038/nn.4640

PMID:28949331

Abstract

摘要

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Unexpected help to repair the cerebellum.修复小脑的意外助力。

Nat Neurosci. 2017 Sep 26;20(10):1319-1321. doi: 10.1038/nn.4640.

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Nat Neurosci. 2017 Oct;20(10):1361-1370. doi: 10.1038/nn.4621. Epub 2017 Aug 14.

The effect of experimental epilepsy induced by penicillin administration during pregnancy on nestin expression in the immature rat cerebellum. A light, electron microscopic, and immunohistochemical study.孕期给予青霉素诱导实验性癫痫对未成熟大鼠小脑巢蛋白表达的影响。一项光镜、电镜及免疫组织化学研究。

Childs Nerv Syst. 2004 Mar;20(3):176-82. doi: 10.1007/s00381-003-0901-3. Epub 2004 Feb 10.

Monoclonal antibodies to a rat nestin fusion protein recognize a 220-kDa polypeptide in subsets of fetal and adult human central nervous system neurons and in primitive neuroectodermal tumor cells.针对大鼠巢蛋白融合蛋白的单克隆抗体可识别胎儿和成人人类中枢神经系统神经元亚群以及原始神经外胚层肿瘤细胞中的一种220 kDa多肽。

Am J Pathol. 1993 Jul;143(1):258-68.

Expression of guanylyl cyclase (GC)-A and GC-B during brain development: evidence for a role of GC-B in perinatal neurogenesis.在大脑发育过程中鸟苷酸环化酶 (GC)-A 和 GC-B 的表达：GC-B 在围生期神经发生中的作用证据。

Endocrinology. 2009 Dec;150(12):5520-9. doi: 10.1210/en.2009-0490. Epub 2009 Oct 16.

A monoclonal antibody recognizing nestin and the phosphorylated form of neurofilament-M.一种识别巢蛋白和神经丝蛋白M磷酸化形式的单克隆抗体。

Dev Neurosci. 1997;19(4):348-56. doi: 10.1159/000111232.

[Nestin mRNA expression during the development of mouse central nervous system].

Sheng Li Xue Bao. 1997 Dec;49(6):657-65.

Plasticity of cultured mesenchymal stem cells: switch from nestin-positive to excitable neuron-like phenotype.培养的间充质干细胞的可塑性：从巢蛋白阳性转变为可兴奋的神经元样表型。

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Description of distributed features of the nestin-containing cells in brains of adult mice: a potential source of neural precursor cells.成年老鼠脑中巢蛋白阳性细胞的分布特征描述：神经前体细胞的潜在来源。

J Neurosci Res. 2010 Apr;88(5):945-56. doi: 10.1002/jnr.22263.

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YAP1 is involved in replenishment of granule cell precursors following injury to the neonatal cerebellum.YAP1 参与了新生小脑损伤后颗粒细胞前体细胞的补充。

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Genetic deletion of genes in the cerebellar rhombic lip lineage can stimulate compensation through adaptive reprogramming of ventricular zone-derived progenitors.小脑菱唇谱系中的基因遗传缺失可通过室管膜来源的祖细胞的适应性重编程来刺激代偿。

Neural Dev. 2019 Feb 14;14(1):4. doi: 10.1186/s13064-019-0128-y.

本文引用的文献

Cerebellar granule cell replenishment postinjury by adaptive reprogramming of Nestin progenitors.损伤后通过巢蛋白祖细胞的适应性重编程实现小脑颗粒细胞的补充。

Nat Neurosci. 2017 Oct;20(10):1361-1370. doi: 10.1038/nn.4621. Epub 2017 Aug 14.

Stimulation of functional neuronal regeneration from Müller glia in adult mice.成年小鼠中缪勒胶质细胞功能性神经元再生的刺激

Nature. 2017 Aug 3;548(7665):103-107. doi: 10.1038/nature23283. Epub 2017 Jul 26.

Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes.不同来源的星形胶质细胞的谱系重编程为不同的神经元亚型。

Stem Cell Reports. 2017 Jul 11;9(1):162-176. doi: 10.1016/j.stemcr.2017.05.009. Epub 2017 Jun 8.

Transplanted embryonic neurons integrate into adult neocortical circuits.移植的胚胎神经元整合到成年新皮层回路中。

Nature. 2016 Nov 10;539(7628):248-253. doi: 10.1038/nature20113. Epub 2016 Oct 26.

Brain repair and reprogramming: the route to clinical translation.脑修复与重编程：通往临床转化之路。

J Intern Med. 2016 Sep;280(3):265-75. doi: 10.1111/joim.12475.

SOX2 reprograms resident astrocytes into neural progenitors in the adult brain.SOX2 将成年大脑中的星形胶质细胞重编程为神经祖细胞。

Stem Cell Reports. 2015 May 12;4(5):780-94. doi: 10.1016/j.stemcr.2015.03.006. Epub 2015 Apr 23.

Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex.Sox2 介导将 NG2 神经胶质细胞在成年大脑皮质损伤中转化为诱导神经元。

Stem Cell Reports. 2014 Dec 9;3(6):1000-14. doi: 10.1016/j.stemcr.2014.10.007. Epub 2014 Nov 20.

In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model.脑损伤和阿尔茨海默病模型中反应性神经胶质细胞在体直接重编程为功能性神经元。

Cell Stem Cell. 2014 Feb 6;14(2):188-202. doi: 10.1016/j.stem.2013.12.001. Epub 2013 Dec 19.

Neural stem cells: generating and regenerating the brain.神经干细胞：生成和再生大脑。

Neuron. 2013 Oct 30;80(3):588-601. doi: 10.1016/j.neuron.2013.10.037.

In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons.在体诱导新生神经元的环路连接重编程。

Nat Neurosci. 2013 Feb;16(2):193-200. doi: 10.1038/nn.3299. Epub 2013 Jan 6.

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Unexpected help to repair the cerebellum.

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