H-1和H-2组胺受体拮抗剂联合应用对一名哮喘患者迟发性哮喘反应的影响。

Effect of combined H-1 and H-2 histamine receptor antagonists on late asthmatic response in an asthmatic patient.

作者信息

Nakazawa T, Umegae Y, Matsui S, Fueki R, Kobayashi S

机构信息

1st Department of Internal Medicine, Gunma University School of Medicine, Japan.

出版信息

J Asthma. 1987;24(6):323-5. doi: 10.3109/02770908709070963.

DOI:10.3109/02770908709070963

PMID:2895098

Abstract

A curious inhibitory effect of histamine H-1 and H-2 antagonists on isolated late asthmatic response (LAR) in an asthmatic patient was observed. When given alone, neither the H-1 nor the H-2 antagonist had an effect on LAR. The combination of drugs, however, provided marked inhibition of LAR. These findings suggest that histamine contributes to some types of LAR.

摘要

观察到组胺H-1和H-2拮抗剂对一名哮喘患者的离体迟发性哮喘反应（LAR）具有一种奇特的抑制作用。单独使用时，H-1拮抗剂和H-2拮抗剂对LAR均无作用。然而，这两种药物联合使用时，对LAR有显著抑制作用。这些发现表明，组胺在某些类型的LAR中起作用。