Oliveira Arão Belitardo, Bachi André Luis Lacerda, Ribeiro Reinaldo Teixeira, Mello Marco Tulio, Tufik Sergio, Peres Mario Fernando Prieto
Federal University of São Paulo, Departament of Neurology and Neurosurgery, 669, Pedro de Toledo, CEP 04039-032 São Paulo, Brazil.
Cruzeiro do Sul University, Physical Activity and Sport Sciences Institute, 868, Galvão Bueno, CEP 01506-000, São Paulo, SP, Brazil.
J Neuroimmunol. 2017 Dec 15;313:138-144. doi: 10.1016/j.jneuroim.2017.09.008. Epub 2017 Sep 20.
Increased plasma pro-inflammatory and decreased anti-inflammatory cytokines have been implicated in physiological and behavioural aspects of mood- and pain-related disorders, including migraine. In this case-control study, we assessed mood scores, cardiorespiratory fitness (VO), and plasma concentrations of TNF-α, IL-1β, IL-6, IL-8, IL-10, and IL-12p70 interictally in women with episodic migraine with/without aura (ICHD-II), taking no preventive medicine, and in healthy women recruited from São Paulo Hospital and local community, respectively. Thirty-seven participants (mean±SD age=34±10 and BMI=26.5±4.9) were assessed. Groups (Control, n=17; Migraine, n=20) showed no differences in age, BMI, and VO. Migraine patients showed higher tension (p=0.019) and anxiety scores (p=0.046), TNF-α (p<0.01), and IL-12p70 (p=0.01), while IL-6 (p<0.01), IL-8 (p<0.01), and IL-10 (p<0.01) were decreased compared to control group. Multiple linear regression models showed that migraine was positively associated with TNF-α and IL-12p70, and negatively associated with IL-6, IL-8, and IL-10. Anxiety scores were positively associated with IL-12p70, and VO was negatively associated with TNF-α. In conclusion, an exaggeratedly skewed cytokine profile, in particular the TNF-α and 12p70/IL-10 balance may be related to migraine pathomechanisms, and its psychiatric comorbidities and functional capacity. Additional studies are needed to confirm these results.
血浆促炎细胞因子增加和抗炎细胞因子减少与情绪和疼痛相关疾病（包括偏头痛）的生理和行为方面有关。在这项病例对照研究中，我们分别对未服用预防性药物、患有发作性偏头痛伴/不伴先兆（国际头痛疾病分类第二版）的女性以及从圣保罗医院和当地社区招募的健康女性进行了发作间期的情绪评分、心肺适能（VO）以及血浆中肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）和白细胞介素-12p70浓度的评估。共评估了37名参与者（平均±标准差年龄=34±10岁，体重指数=26.5±4.9）。两组（对照组，n = 17；偏头痛组，n = 20）在年龄、体重指数和VO方面无差异。偏头痛患者的紧张程度（p = 0.019）和焦虑评分（p = 0.046）、TNF-α（p < 0.01）和IL-12p70（p = 0.01）较高，而与对照组相比，IL-6（p < 0.01）、IL-8（p < 0.01）和IL-10（p < 0.01）降低。多元线性回归模型显示，偏头痛与TNF-α和IL-12p70呈正相关，与IL-6、IL-8和IL-10呈负相关。焦虑评分与IL-12p70呈正相关，VO与TNF-α呈负相关。总之，细胞因子谱过度失衡，尤其是TNF-α和12p70/IL-10平衡可能与偏头痛的发病机制及其精神共病和功能能力有关。需要进一步的研究来证实这些结果。
