Yang Fan, Liu Hai-Zhen, Liu Jia-Ai, Chen Yao-Yao, Sun Su-Zhen
Department of Pediatrics, Hebei Medical University, Shijiazhuang, China.
International Liaison Office, Hebei Children's Hospital, Shijiazhuang, China.
Front Neurol. 2024 Jan 31;15:1347387. doi: 10.3389/fneur.2024.1347387. eCollection 2024.
To compare the serum levels of 12 cytokines in migraine group, encephalitis with headache symptoms group, pneumonia without headache symptoms group and migraine subgroups to explore the cytokines associated with migraine in children and their levels.
A total of 44 children with migraine, 27 children in the encephalitis group with headache symptoms and 44 children in the pneumonia group without headache symptoms were selected from January 2022 to August 2023 in Hebei Children's Hospital. They were all tested for serum cytokines by immunofluorescence assay. The migraine group was further divided into subgroups according to different age, gender, course of disease, and presence of coinfection. The differences of serum cytokine levels among the above groups were compared, and the correlation analysis was carried out.
Except IL-5, there were no significant differences in the expression levels of other 11 inflammatory cytokines between migraine subgroups. Compared with encephalitis with headache symptoms group and pneumonia without headache symptoms group the serum levels of IL-4, TNF-α, IL-17A, and IL-12p70 were higher in migraine group than in pneumonia group, and the levels of IL-12p70 were higher than those in encephalitis group ( < 0.05). An increase in serum IL-12p70 ( = 1.267, 95%CI 1.054-1.523, = 0.012) and IL-17A ( = 1.066, 95%CI 1.016-1.119, = 0.010) levels had a significant effect on migraine.
Elevated serum levels of IL-12p70 and IL-17A may increase the risk of migraine in children, which has certain diagnostic and predictive value.
比较偏头痛组、有头痛症状的脑炎组、无头痛症状的肺炎组及偏头痛亚组血清中12种细胞因子水平，以探索儿童偏头痛相关细胞因子及其水平。
选取2022年1月至2023年8月在河北省儿童医院就诊的44例偏头痛患儿、27例有头痛症状的脑炎组患儿和44例无头痛症状的肺炎组患儿，均采用免疫荧光法检测血清细胞因子。偏头痛组根据年龄、性别、病程及是否合并感染进一步分为亚组。比较上述各组血清细胞因子水平差异，并进行相关性分析。
除IL-5外，偏头痛各亚组间其他11种炎性细胞因子表达水平差异无统计学意义。与有头痛症状的脑炎组和无头痛症状的肺炎组相比，偏头痛组血清IL-4、TNF-α、IL-17A和IL-12p70水平高于肺炎组，且IL-12p70水平高于脑炎组（<0.05）。血清IL-12p70水平升高（=1.267，95%CI 1.054-1.523，=0.012）和IL-17A水平升高（=1.066，95%CI 1.016-1.119，=0.010）对偏头痛有显著影响。
血清IL-12p70和IL-17A水平升高可能增加儿童偏头痛发病风险，具有一定诊断及预测价值。
