School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Australia.
School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Australia; Amsterdam Brain and Cognition, University of Amsterdam, Netherlands.
Neurosci Biobehav Rev. 2017 Dec;83:11-20. doi: 10.1016/j.neubiorev.2017.09.023. Epub 2017 Sep 23.
The aetiology of various psychiatric and neurological disorders may be partially attributable to impairments in neuroplasticity. Developing novel methods of stimulating neuroplasticity is a promising treatment approach to counterbalance these maladaptive influences and alleviate symptomologies. Two non-pharmacological approaches with significant and direct impacts on neuroplasticity are aerobic exercise and repetitive transcranial magnetic stimulation. Aerobic exercise is associated with the promotion of numerous neurotrophic mechanisms at a molecular and cellular level, which have a broad influence on neuroplasticity. Transcranial magnetic stimulation is a form of non-invasive brain stimulation with the capacity to modulate the synaptic efficacy and connectivity of particular brain networks. This review synthesises extant literature to explore the complementary physiological mechanisms targeted by aerobic exercise and repetitive transcranial magnetic stimulation, and to substantiate the hypothesis that the use of these techniques in tandem may result in synergistic impact on neural mechanisms to achieve a more efficacious therapeutic approach for mental disorders.
各种精神和神经紊乱的病因可能部分归因于神经可塑性的损伤。开发新的刺激神经可塑性的方法是一种有前途的治疗方法，可以抵消这些适应不良的影响，减轻症状。两种对神经可塑性有重大和直接影响的非药物治疗方法是有氧运动和重复经颅磁刺激。有氧运动与分子和细胞水平上多种神经营养机制的促进有关，这些机制对神经可塑性有广泛的影响。经颅磁刺激是一种非侵入性的脑刺激形式，具有调节特定脑网络的突触效能和连接性的能力。本综述综合了现有文献，以探讨有氧运动和重复经颅磁刺激所针对的互补生理机制，并证实使用这些技术联合使用可能会对神经机制产生协同影响，从而为精神障碍的治疗方法提供更有效的治疗方法。
