Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695014, Kerala, India.
Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Pharmacol Res. 2018 Apr;130:273-291. doi: 10.1016/j.phrs.2017.12.034. Epub 2018 Jan 4.
Inflammation is one of the major causative factor of cancer and chronic inflammation is involved in all the major steps of cancer initiation, progression metastasis and drug resistance. The molecular mechanism of inflammation driven cancer is the complex interplay between oncogenic and tumor suppressive transcription factors which include FOXM1, NF-kB, STAT3, Wnt/β- Catenin, HIF-1α, NRF2, androgen and estrogen receptors. Several products derived from natural sources modulate the expression and activity of multiple transcription factors in various tumor models as evident from studies conducted in cell lines, pre-clinical models and clinical samples. Further combination of these natural products along with currently approved cancer therapies added an additional advantage and they considered as promising targets for prevention and treatment of inflammation and cancer. In this review we discuss the application of multi-targeting natural products by analyzing the literature and future directions for their plausible applications in drug discovery.
炎症是癌症的主要致病因素之一，慢性炎症涉及癌症发生、进展、转移和耐药的所有主要步骤。炎症驱动癌症的分子机制是致癌和肿瘤抑制转录因子之间的复杂相互作用，包括 FOXM1、NF-κB、STAT3、Wnt/β-连环蛋白、HIF-1α、NRF2、雄激素和雌激素受体。来自天然来源的几种产品可调节多种转录因子在各种肿瘤模型中的表达和活性，这从在细胞系、临床前模型和临床样本中进行的研究中可以明显看出。这些天然产物与目前批准的癌症治疗方法相结合，增加了额外的优势，被认为是预防和治疗炎症和癌症的有前途的靶点。在这篇综述中，我们通过分析文献讨论了多靶向天然产物的应用，并为它们在药物发现中的可能应用提出了未来的方向。
