Department of Neurology, Zhuji People's Hospital of Zhejiang Province, Zhuji 311800, China.
Department of Neurology, Zhuji People's Hospital of Zhejiang Province, Zhuji 311800, China.
J Neuroimmunol. 2019 Oct 15;335:577004. doi: 10.1016/j.jneuroim.2019.577004. Epub 2019 Jul 9.
Some previous studies already explored associations of interleukin-6 (IL-6) and interleukin-10 (IL-10) polymorphisms with ischemic stroke (IS). However, the results were conflicting. In this meta-analysis, we aimed to better analyze the relationship between IL-6/IL-10 polymorphisms and IS in a larger pooled population.
We performed a systematic search of PubMed, Web of Science, Embase and CNKI. We calculated pooled odds ratios (ORs) and 95% confidence intervals (CIs) to estimate associations between IL-6/IL-10 polymorphisms and IS.
Totally 37 studies were included for analyses. A significant association with IS was observed for IL-10 rs1800896 polymorphism in AA versus GG + GA (recessive model, p = .001, OR = 1.42, 95%CI 1.15-1.75) in overall population. Further subgroup analyses showed that IL-6 rs1800795 was significantly associated with IS in Asians in GG versus GC + CC (dominant model, p = .0005, OR = 0.74, 95%CI 0.62-0.88), CC versus GG + GC (recessive model, p = .003, OR = 1.61, 95%CI 1.17-2.21) and G versus C (allele model, p = .01, OR = 0.74, 95%CI 0.58-0.93), whereas IL-10 rs1800896 polymorphism was significantly associated with cerebral infarction (CI) in GG versus GA + AA (dominant model, p = .02, OR = 2.04, 95%CI 1.14-3.64), GA versus GG + AA (overdominant model, p = .03, OR = 0.50, 95%CI 0.27-0.93) and G versus A (allele model, p = .01, OR = 1.92, 95%CI 1.16-3.17).
Our findings indicated that IL-6 rs1800795 polymorphism was significantly associated with individual susceptibility to IS in Asians, but not in Caucasians. In addition, IL-10 rs1800896 polymorphism was also significantly associated with individual susceptibility to IS, especially for CI.
已有一些研究探讨了白细胞介素-6（IL-6）和白细胞介素-10（IL-10）多态性与缺血性脑卒中（IS）的关联。然而，结果存在争议。在本荟萃分析中，我们旨在通过更大的汇总人群更好地分析 IL-6/IL-10 多态性与 IS 之间的关系。
我们对 PubMed、Web of Science、Embase 和中国知网进行了系统检索。我们计算了合并的优势比（OR）和 95%置信区间（CI），以评估 IL-6/IL-10 多态性与 IS 之间的关联。
共有 37 项研究纳入分析。在总体人群中，IL-10 rs1800896 多态性在 AA 与 GG+GA（隐性模型，p=0.001，OR=1.42，95%CI 1.15-1.75）中与 IS 显著相关。进一步的亚组分析显示，在亚洲人群中，IL-6 rs1800795 在 GG 与 GC+CC（显性模型，p=0.0005，OR=0.74，95%CI 0.62-0.88）、CC 与 GG+GC（隐性模型，p=0.003，OR=1.61，95%CI 1.17-2.21）和 G 与 C（等位基因模型，p=0.01，OR=0.74，95%CI 0.58-0.93）中与 IS 显著相关，而 IL-10 rs1800896 多态性在 GG 与 GA+AA（显性模型，p=0.02，OR=2.04，95%CI 1.14-3.64）、GA 与 GG+AA（超显性模型，p=0.03，OR=0.50，95%CI 0.27-0.93）和 G 与 A（等位基因模型，p=0.01，OR=1.92，95%CI 1.16-3.17）中与脑梗死（CI）显著相关。
我们的研究结果表明，IL-6 rs1800795 多态性与亚洲人群 IS 的个体易感性显著相关，但与高加索人群无关。此外，IL-10 rs1800896 多态性也与 IS 的个体易感性显著相关，特别是与 CI 相关。
