与纳米晶二氧化铈结合的超氧化物歧化酶和过氧化氢酶的抗氧化活性
Antioxidant Activity of SOD and Catalase Conjugated with Nanocrystalline Ceria.
作者信息
Gil Dmitry, Rodriguez Jeannette, Ward Brendan, Vertegel Alexey, Ivanov Vladimir, Reukov Vladimir
机构信息
Department of Bioengineering, Clemson University, 301 Rhodes Hall, Clemson, SC 29634, USA.
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii pr. 31, 119991 Moscow, Russia.
出版信息
Bioengineering (Basel). 2017 Feb 25;4(1):18. doi: 10.3390/bioengineering4010018.
Interactions of nanoparticles with biological matter-both somatically and in nature-draw scientists' attention. Nanoparticulate systems are believed to be our saviors, acting as versatile drug delivery vehicles. However, they can also cause life-threatening bodily damage. One of the most important properties of nanocrystalline cerium dioxide is its antioxidant activity, which decreases the abundance of reactive oxygen species during inflammation. In this paper, we report on synergistic effects of inorganic cerium oxide (IV) nanoparticles conjugated with the antioxidative enzymes superoxide dismutase and catalase on scavenging oxygen and nitrogen radicals.
纳米颗粒与生物物质在体细胞层面以及自然环境中的相互作用引起了科学家们的关注。纳米颗粒系统被认为是我们的救星，可作为多功能药物递送载体。然而，它们也可能造成危及生命的身体损伤。纳米晶二氧化铈最重要的特性之一是其抗氧化活性，它能在炎症过程中降低活性氧的丰度。在本文中，我们报告了与抗氧化酶超氧化物歧化酶和过氧化氢酶共轭的无机氧化铈（IV）纳米颗粒在清除氧自由基和氮自由基方面的协同作用。
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