Gupta Surabhi, Chaudhary Priyanka, Muniyappan Nalluchamy, Sabiah Shahulhameed, Kandasamy Jeyakumar
Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh-221005, India.
Org Biomol Chem. 2017 Oct 18;15(40):8493-8498. doi: 10.1039/c7ob02234d.
The copper meditated N-methylation of sulfoximines using methylboronic acid is reported. The reactions provide excellent yields in a short span of time under mild conditions. The optimized conditions were also found to be suitable for the N-alkylation of sulfoximine with different alkylboronic acids. In addition, N-methylation and cyclopropylation of the bioactive l-methionine sulfoximine derivative was demonstrated under standard reaction conditions.
报道了使用甲基硼酸对磺胺氧化亚胺进行铜介导的N-甲基化反应。该反应在温和条件下短时间内即可提供优异的产率。还发现优化后的条件适用于磺胺氧化亚胺与不同烷基硼酸的N-烷基化反应。此外，在标准反应条件下证明了生物活性L-蛋氨酸磺胺氧化亚胺衍生物的N-甲基化和环丙基化反应。
