Department of Dermatology, Erasmus MC University Medical Centre, Postbus 2040, NL-3000 CA Rotterdam, The Netherlands.
Acta Derm Venereol. 2018 Feb 7;98(2):234-239. doi: 10.2340/00015555-2806.
Health-related quality of life (HRQoL) is important in the management of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Disease-specific questionnaires exist, but with important shortcomings. The aim of this study was to develop and validate a questionnaire suitable for use in all patients with BCC and those with SCC. In a 4-phase trajectory, a preliminary questionnaire was created and population-based testing (1,173 patients) carried out. The questionnaire was reduced using exploratory factor analysis and item response theory. Individual item performance was assessed using classical test theory. A total of 721 patients completed the questionnaire. The number of items was reduced to 16, covering 5 scales. Confirmatory factor analysis showed a good fit. Cronbach�s ?s (range 0.67�0.82) were reasonable to high with good internal consistency. In conclusion, the Basal and Squamous Cell Carcinoma Quality of Life questionnaire has good face, content and construct validity. It is useful in the wide range of BCC and SCC patients and captures HRQoL impact over different time-frames.
健康相关生活质量（HRQoL）在基底细胞癌（BCC）和鳞状细胞癌（SCC）的管理中很重要。存在疾病特异性问卷，但存在重要的缺点。本研究旨在开发和验证一种适用于所有 BCC 患者和 SCC 患者的问卷。在 4 个阶段的轨迹中，创建了一个初步的问卷，并进行了基于人群的测试（1173 名患者）。使用探索性因子分析和项目反应理论对问卷进行了简化。使用经典测试理论评估单个项目的性能。共有 721 名患者完成了问卷。项目数量减少到 16 个，涵盖 5 个量表。验证性因子分析显示拟合良好。克朗巴赫 α系数（范围 0.67�0.82）在良好到高度之间，具有良好的内部一致性。总之，基底细胞癌和鳞状细胞癌生活质量问卷具有良好的表面、内容和结构效度。它在广泛的 BCC 和 SCC 患者中都有用，并能捕捉到不同时间框架内的 HRQoL 影响。
