Matthews B Alex, Rhee John S, Neuburg Marcy, Burzynski Mary L, Nattinger Ann B
Health Policy Institute, Center for Patient Care & Outcomes Research, Department of Otolaryngology and Communication Sciences, Froedtert Memorial Lutheran Hospital and Medical College of Wisconsin, Milwaukee, Wisconsin 53226-0509, USA.
Dermatol Surg. 2006 Jul;32(7):924-34; discussion 934. doi: 10.1111/j.1524-4725.2006.32197.x.
Existing health-related quality-of-life (HRQOL) tools do not appear to capture patients' specific skin cancer concerns.
To describe the conceptual foundation, item generation, reduction process, and reliability testing for the Facial Skin Cancer Index (FSCI), a HRQOL outcomes tool for skin cancer researchers and clinicians.
Participants in Phases I to III consisted of adult patients (N=134) diagnosed with biopsy-proven nonmelanoma cervicofacial skin cancer. Data were collected via self-report surveys and clinical records.
Seventy-one distinct items were generated in Phase I and rated for their importance by an independent sample during Phase II; 36 items representing six theoretical HRQOL domains were retained. Test-retest I results indicated that four subscales showed adequate reliability coefficients (alpha=0.60 to 0.91). Twenty-six items remained for test-retest II. Results indicated excellent internal consistency for emotional, social, appearance, and modified financial/work subscales (range 0.79 to 0.95); test-retest correlation coefficients were consistent across time (range 0.81 to 0.97; lifestyle omitted).
Pretesting afforded the opportunity to select items that optimally met our a priori conceptual and psychometric criteria for high data quality. Phase IV testing (validity and sensitivity before surgery and 4 months after Mohs micrographic surgery) for the 20-item FSCI is under way.
现有的健康相关生活质量（HRQOL）工具似乎无法涵盖患者对皮肤癌的具体担忧。
描述面部皮肤癌指数（FSCI）的概念基础、条目生成、缩减过程和信度测试，这是一种供皮肤癌研究人员和临床医生使用的HRQOL结果工具。
第一阶段至第三阶段的参与者为经活检证实患有非黑色素瘤面颈部皮肤癌的成年患者（N = 134）。数据通过自我报告调查和临床记录收集。
第一阶段生成了71个不同的条目，并在第二阶段由一个独立样本对其重要性进行评分；保留了代表六个理论HRQOL领域的36个条目。重测I结果表明，四个子量表显示出足够的信度系数（α = 0.60至0.91）。26个条目留作重测II。结果表明，情感、社会、外观和修改后的财务/工作子量表具有出色的内部一致性（范围为0.79至0.95）；重测相关系数在不同时间是一致的（范围为0.81至0.97；生活方式部分省略）。
预测试提供了选择条目的机会，这些条目最佳地满足了我们对高数据质量的先验概念和心理测量标准。20条目FSCI的第四阶段测试（手术前和莫氏显微外科手术后4个月的效度和敏感性）正在进行中。
