Tang Ke-Qiang, Yang Shao-Ling, Zhang Bin, Liu Hong-Xiang, Ye Dong-Ying, Zhang Hong-Ze, Ma Shuang
Emergency Critical Care Division, Shanghai Songjiang District Central Hospital, Songjiang Branch of the Affiliated First People's Hospital of Shanghai Jiao Tong University Department of Cardiac Vascular Ultrasound, Shanghai Fengxian District Central Hospital, Shanghai, China.
Medicine (Baltimore). 2017 Sep;96(39):e8168. doi: 10.1097/MD.0000000000008168.
The aim of this study was to explore the clinical value of ultrasonic monitoring in the assessment of pulmonary recruitment and the best positive end-expiratory pressure (PEEP).Between January 2015 and June 2017, 40 patients with acute respiratory distress syndrome in our hospital were randomly divided into 2 groups: ultrasound group (ULS group; n = 20) and oxygenation group (OXY group; n = 20). The PEEP incremental method was used to perform recruitment maneuvers. Ultrasound scoring and the oxygenation method were used to evaluate the pulmonary recruitment endpoint. The best PEEP was chosen by ultrasound scoring and the oxygenation method after achieving the pulmonary recruitment endpoint and sustaining it for 15 minutes.The oxygenation index, PEEP, peak airway pressure (Ppeak), mean airway pressure (Pmean), and dynamic compliance (Cdyn) in the OXY group were significantly lower than those in the ULS group (P < .05) at the pulmonary recruitment endpoint; however, there was no statistical significance in the mean arterial blood pressure (MAP) or heart rate (HR) (P > .05). The best PEEPs in the OXY and ULS groups were 13.1 ± 3.1 and 15.7 ± 4.2 cmH2O, respectively, with a significant difference between the 2 groups (t = 2.227, P = .016). Compared with the basal state, the Cdyn, oxygenation index, Pmean, and Ppeak in both groups significantly increased after pulmonary recruitment (P < .05). Furthermore, the Cdyn and oxygenation index in the ULS group were significantly higher than those in the OXY group after pulmonary recruitment (P < .05). The HR in both groups significantly increased, and the MAP significantly decreased. Two hours after recruitment, the HR and MAP returned to near basal levels without a significant difference between the 2 groups (P > .05).Lung ultrasound can be used to detect the endpoint of lung recruitment and the best PEEP, with good effects on lung compliance and oxygenation improvement.
本研究旨在探讨超声监测在评估肺复张及最佳呼气末正压(PEEP)中的临床价值。2015年1月至2017年6月,我院40例急性呼吸窘迫综合征患者被随机分为2组:超声组(ULS组;n = 20)和氧合组(OXY组;n = 20)。采用PEEP递增法进行肺复张操作。采用超声评分和氧合法评估肺复张终点。在达到肺复张终点并维持15分钟后,通过超声评分和氧合法选择最佳PEEP。在肺复张终点时,OXY组的氧合指数、PEEP、气道峰压(Ppeak)、平均气道压(Pmean)和动态顺应性(Cdyn)显著低于ULS组(P <.05);然而,平均动脉血压(MAP)或心率(HR)无统计学意义(P >.05)。OXY组和ULS组的最佳PEEP分别为13.1±3.1和15.7±4.2 cmH2O,两组间差异有统计学意义(t = 2.227,P = 0.016)。与基础状态相比,两组肺复张后Cdyn、氧合指数、Pmean和Ppeak均显著升高(P <.05)。此外,肺复张后ULS组的Cdyn和氧合指数显著高于OXY组(P <.05)。两组HR均显著升高,MAP显著降低。肺复张后2小时,HR和MAP恢复至接近基础水平,两组间无显著差异(P >.05)。肺部超声可用于检测肺复张终点及最佳PEEP,对改善肺顺应性和氧合有良好效果。