Campos Gabriela Rached, Boin Ilka de Fátima Santana Ferreira, Campos Ivan Dias de, Cintra Maria Letícia
Post-Graduation Program in Surgery Sciences of School of Medical Sciences of Universidade Estadual de Campinas (FCM-Unicamp) - Campinas (SP), Brazil.
Department of Surgery of School of Medical Sciences of Universidade Estadual de Campinas (FCM-Unicamp) - Campinas (SP), Brazil.
An Bras Dermatol. 2017 Jul-Aug;92(4):492-498. doi: 10.1590/abd1806-4841.20175946.
: Many factors are currently being identified as potential inductors of skin cancer in patients after a liver transplant, among them, immunosuppressive regimen.
: To study the factors that influence the incidence of skin cancer in patients after liver transplant.
: We have carried out a retrospective and observational study with 170 transplanted patients who had undergone transplantation from 1997 to 2010. We have adjusted the multiple logistic regression model (saturated model) to the ensemble of collected data using skin cancer as dependent variable, indicated in anatomopathological analysis between 1997 and 2014.
: Incidence of skin cancer was 9.4%. Predictors were incidence of diabetes in the third year after the transplantation (p=0.047), not using tacrolimus in the first year after the transplantation (p=0.025) and actinic keratosis (p=0.003).
: An important limitation is that the interpretation of the results was based on information collected of patients undergoing transplantation at a single center. Future research, multicentric and involving larger and more diverse populations, are needed.
: Factors found might contribute to Brazilian surveillance programs associated with decreased incidence of skin cancer.
目前许多因素被认为是肝移植患者皮肤癌的潜在诱发因素，其中包括免疫抑制方案。
研究影响肝移植患者皮肤癌发病率的因素。
我们对1997年至2010年接受移植的170例患者进行了一项回顾性观察研究。我们将多因素逻辑回归模型（饱和模型）应用于收集的数据，以1997年至2014年解剖病理学分析中显示的皮肤癌为因变量。
皮肤癌发病率为9.4%。预测因素为移植后第三年糖尿病的发病率（p = 0.047）、移植后第一年未使用他克莫司（p = 0.025）和光化性角化病（p = 0.003）。
一个重要的局限性是结果的解释基于在单一中心接受移植患者收集的信息。需要开展多中心、涉及更大和更多样化人群的未来研究。
发现的因素可能有助于巴西开展与降低皮肤癌发病率相关的监测项目。
