Juge Pierre-Antoine, Berard Laure, Kotti Salma, Doursounian Levon, Sautet Alain, Simon Tabassome, Berenbaum Francis, Nourissat Geoffroy, Sellam Jérémie
Rheumatology Department, Saint-Antoine hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Univ Paris 06, Inserm UMRS_938, DHU i2B, Paris, France.
Rheumatology Department, Le Havre Hospital, Le Havre, France.
RMD Open. 2017 Jun 29;3(1):e000429. doi: 10.1136/rmdopen-2016-000429. eCollection 2017.
Risk factors for shoulder osteoarthritis (SOA) have been poorly studied. SOA has two anatomical subtypes: primary centred SOA (centred SOA) and rotator cuff-related OA (non-centred SOA). We examined whether cardiometabolic risk factors are preferentially associated with centred than mechanical-induced non-centred SOA.
This 2004-2012 retrospective multicentric study included patients with SOA. Data on clinical characteristics, especially cardiometabolic risk factors, were collected. We compared patients with radiographic-centred and non-centred SOA and tested the association between cardiometabolic risk factors and subtypes of SOA.
We included 147 patients (101 women (68.7%); mean age 75.8±10 years); 99 had centred SOA. As compared with patients with non-centred SOA, those with centred SOA were older (77.5±9 vs 72.4±11 years; p=0.004) with no difference in cardiometabolic disturbances or their accumulation. Multivariable analyses indicated that older age was independently associated with centred SOA (OR 1.06;95% CI 1.02 to 1.1; p=0.004), and cardiovascular diseases were less associated with this subtype (OR 0.27; 95% CI 0.089 to 0.824; p=0.02) than with the non-centred one.
Cardiometabolic risk factors were not more prevalent with primary centred than rotator cuff-related SOA. They may participate in the pathophysiology of both SOA subtypes through cartilage and tendon disruption.
肩骨关节炎（SOA）的危险因素尚未得到充分研究。SOA有两种解剖学亚型：原发性中心性SOA（中心性SOA）和肩袖相关骨关节炎（非中心性SOA）。我们研究了心血管代谢危险因素是否比机械性诱导的非中心性SOA更易与中心性SOA相关。
这项2004 - 2012年的回顾性多中心研究纳入了SOA患者。收集了关于临床特征的数据，尤其是心血管代谢危险因素。我们比较了影像学诊断为中心性和非中心性SOA的患者，并测试了心血管代谢危险因素与SOA亚型之间的关联。
我们纳入了147例患者（101例女性（68.7%）；平均年龄75.8±10岁）；99例患有中心性SOA。与非中心性SOA患者相比，中心性SOA患者年龄更大（77.5±9岁对72.4±11岁；p = 0.004），心血管代谢紊乱或其累积情况无差异。多变量分析表明，年龄较大与中心性SOA独立相关（OR 1.06；95% CI 1.02至1.1；p = 0.004），与非中心性SOA相比，心血管疾病与该亚型的关联较小（OR 0.27；95% CI 0.089至0.824；p = 0.02）。
心血管代谢危险因素在原发性中心性SOA中并不比肩袖相关SOA更普遍。它们可能通过软骨和肌腱破坏参与两种SOA亚型的病理生理过程。
