Denic S, Abramson J, Anandakrishnan R, Krishnamurthy M, Dosik H
Division of Hematology/Oncology, Interfaith Medical Center--State University of New York Health Science Center, Brooklyn 11238.
Am J Hematol. 1988 Apr;27(4):281-3. doi: 10.1002/ajh.2830270410.
Two patients, a daughter and her father, developed the acute type of adult T-cell leukemia/lymphoma (ATLL) within a 3-month period. Antibodies against HTLV-I have been found in both wives of the father. The second wife acquired the infection from her husband within 3 years of marriage. The patients described represent the first cases of familial ATLL in the United States. ATLL continues to be frequently misdiagnosed in the United States. A positive family history consistent with this disease in a patient with a lymphoid malignancy may be a helpful clue for earlier diagnosis.
两名患者，一名女儿及其父亲，在3个月内患上了急性成人T细胞白血病/淋巴瘤（ATLL）。在父亲的两位妻子体内均发现了抗人类T淋巴细胞病毒I型（HTLV-I）抗体。第二任妻子在婚后3年内从丈夫那里感染了该病毒。所描述的这些患者代表了美国首例家族性ATLL病例。在美国，ATLL仍经常被误诊。对于患有淋巴系统恶性肿瘤的患者，与这种疾病相符的阳性家族史可能是早期诊断的一个有用线索。
