Cordiano Raffaele, Papa Vincenzo, Cicero Nicola, Spatari Giovanna, Allegra Alessandro, Gangemi Sebastiano
Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy.
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98168 Messina, Italy.
Toxics. 2022 Nov 9;10(11):678. doi: 10.3390/toxics10110678.
Literature is teeming with publications on industrial pollution. Over the decades, the main industrial pollutants and their effects on human health have been widely framed. Among the various compounds involved, benzene plays a leading role in the onset of specific diseases. Two systems are mainly affected by the adverse health effects of benzene exposure, both acute and chronic: the respiratory and hematopoietic systems. The most suitable population targets for a proper damage assessment on these systems are oil refinery workers and residents near refining plants. Our work fits into this area of interest with the aim of reviewing the most relevant cases published in the literature related to the impairment of the aforementioned systems following benzene exposure. We perform an initial debate between the two clinical branches that see a high epidemiological expression in this slice of the population examined: residents near petroleum refinery areas worldwide. In addition, the discussion expands on highlighting the main immunological implications of benzene exposure, finding a common pathophysiological denominator in inflammation, oxidative stress, and DNA damage, thus helping to set the basis for an increasingly detailed characterization aimed at identifying common molecular patterns between the two clinical fields discussed.
关于工业污染的出版物在文献中比比皆是。几十年来，主要的工业污染物及其对人类健康的影响已得到广泛阐述。在涉及的各种化合物中，苯在特定疾病的发病中起主要作用。苯暴露的急性和慢性健康不良影响主要涉及两个系统：呼吸系统和造血系统。对这些系统进行适当损害评估的最合适人群目标是炼油厂工人和炼油厂附近的居民。我们的工作属于这一感兴趣的领域，目的是回顾文献中发表的与苯暴露后上述系统受损相关的最相关案例。我们在两个临床分支之间进行了初步辩论，这两个分支在我们所研究的这部分人群中具有较高的流行病学表现：全球炼油厂附近的居民。此外，讨论还扩展到突出苯暴露的主要免疫学影响，在炎症、氧化应激和DNA损伤中找到共同的病理生理特征，从而有助于为日益详细的特征描述奠定基础，旨在确定所讨论的两个临床领域之间的共同分子模式。
