Marhuenda Javier, Medina Sonia, Martínez-Hernández Pedro, Arina Simon, Zafrilla Pilar, Mulero Juana, Oger Camille, Galano Jean-Marie, Durand Thierry, Solana Antonio, Ferreres Federico, López-García Juan José, Gil-Izquierdo Angel
Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Campus University Espinardo, Murcia, Spain.
Food Funct. 2017 Oct 18;8(10):3745-3757. doi: 10.1039/c7fo01081h.
Oxylipins are lipid mediators involved in the physiopathology of all organs. Moreover, isoprostanes have been established as general and reliable in vivo oxidative stress biomarkers. Red wine has proved to exert several benefits through the maintenance of the oxidative balance of the organism. Antiradical scavenging capacity has been mainly attributed to polyphenols. However, melatonin and hydroxytyrosol should be taken into account as potent antiradical agents. The present research aimed to clarify the situation of enzymatic and oxidative injury and eicosanoid urinary excretion related to the intake of three kinds of red wines and their primary musts. Judging by the reduction in the excretion of isoprostanes, red wine consumption exhibited the highest antioxidant protection against oxidative stress, attributed to its OHTyr content (p < 0.05), and to a lesser extent to its MEL content. Similarly, the intake of red wine leads to the cardioprotective effect due to the reduction in the urinary excretion of the pro-inflammatory prostaglandin 2,3-dinor-11-β-PGF, besides the increase in the vasodilator prostaglandin PGE, mediated by the melatonin (p < 0.05) and hydroxytyrosol (p < 0.05) contents. In conclusion, red wine (especially non-aged wine) exerts a higher in vivo antioxidant capacity than must or alcohol.
氧化脂质是参与所有器官生理病理学过程的脂质介质。此外，异前列腺素已被确立为体内普遍且可靠的氧化应激生物标志物。红酒已被证明通过维持机体的氧化平衡发挥多种益处。抗自由基清除能力主要归因于多酚类物质。然而，褪黑素和羟基酪醇也应被视为有效的抗自由基剂。本研究旨在阐明与三种红酒及其原酒摄入相关的酶性和氧化性损伤以及类花生酸尿排泄情况。从异前列腺素排泄量的减少来看，饮用红酒对氧化应激表现出最高的抗氧化保护作用，这归因于其羟基酪醇含量（p < 0.05），在较小程度上也归因于其褪黑素含量。同样，饮用红酒除了通过褪黑素（p < 0.05）和羟基酪醇（p < 0.05）含量介导使血管舒张前列腺素PGE增加外，还因促炎前列腺素2,3 - 二去甲 - 11 - β - PGF的尿排泄量减少而产生心脏保护作用。总之，红酒（尤其是未陈酿的葡萄酒）在体内的抗氧化能力高于原酒或酒精。
