Faculty of Health Sciences, San Antonio Catholic University of Murcia (UCAM), 30107 Murcia, Spain.
Primary Care Research Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain.
Molecules. 2021 Mar 22;26(6):1783. doi: 10.3390/molecules26061783.
Hypertension is an important factor of cardiovascular diseases and contributes to their negative consequences including mortality. The World Health Organization estimated that 54% of strokes and 47% of cases of ischemic heart illness are related to high blood pressure. Recently, (HS) and (LC) have attracted scientific interest, and they are recognized for their high content of polyphenols as these may prevent several disease factors, such as hypertension. The aim of the present study is to determine if supplementation with an HS-LC blend (MetabolAid) may be effective for the treatment of type 1 hypertensive sedentary populations. A total of 80 type 1 hypertensive subjects of both sexes were included in the study and were treated with placebo or the HS-LC extract, and both groups were treated over 84 days. The blood pressure (diastolic, systolic, and pulse pressure) was measured throughout the day, for each of the days of the study duration and determined using Ambulatory Blood Pressure Monitoring (ABPM). Physical activity was determined throughout the study to ensure similar conditions related to exercise. The results showed the capacity for reducing the blood pressure parameters in the case of the HS-LC extract. The daily consumption of the HS-LC extract but not the placebo over 84 days was able to reduce the daytime parameters related to blood pressure. The most remarkable results were observed in the measurements performed during the daytime, especially in the systolic blood pressure showing statistically significant variation.
高血压是心血管疾病的一个重要因素，也是导致其不良后果（包括死亡率）的一个因素。世界卫生组织估计，54%的中风和 47%的缺血性心脏病病例与高血压有关。最近，（HS）和（LC）引起了科学界的兴趣，由于其高含量的多酚，被认为可以预防高血压等多种疾病因素。本研究的目的是确定 HS-LC 混合物（MetabolAid）补充剂是否对治疗 1 型高血压静坐人群有效。共有 80 名 1 型高血压的男女受试者被纳入研究，并接受安慰剂或 HS-LC 提取物治疗，两组均在 84 天内接受治疗。全天、每天的研究期间，通过动态血压监测（ABPM）测量血压（舒张压、收缩压和脉压）。在整个研究过程中，通过确定身体活动，确保与运动相关的条件相似。结果表明，HS-LC 提取物具有降低血压参数的能力。在 84 天的时间内，HS-LC 提取物的日常摄入量，而不是安慰剂，能够降低日间血压相关参数。在白天进行的测量中观察到了最显著的结果，特别是在收缩压方面，显示出统计学上的显著变化。
