Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Integrated Research and Treatment Centre Transplantation (IFB-Tx), Hannover Medical School, 30625 Hannover, Germany.
Cardiovasc Res. 2017 Oct 1;113(12):1433-1440. doi: 10.1093/cvr/cvx153.
Right ventricular (RV) remodelling is a lesser understood process of the chronic, progressive transformation of the RV structure leading to reduced functional capacity and subsequent failure. Besides conditions concerning whole hearts, some pathology selectively affects the RV, leading to a distinct RV-specific clinical phenotype. MicroRNAs have been identified as key regulators of biological processes that drive the progression of chronic diseases. The role of microRNAs in diseases affecting the left ventricle has been studied for many years, however there is still limited information on microRNAs specific to diseases in the right ventricle. Here, we review recently described details on the expression, regulation, and function of microRNAs in the pathological remodelling of the right heart. Recently identified strategies using microRNAs as pharmacological targets or biomarkers will be highlighted. Increasing knowledge of pathogenic microRNAs will finally help improve our understanding of underlying distinct mechanisms and help utilize novel targets or biomarkers to develop treatments for patients suffering from right heart diseases.
右心室（RV）重构是一个对慢性、进行性 RV 结构改变过程的理解较少的过程，导致功能能力降低和随后的衰竭。除了涉及整个心脏的情况外，一些病理学选择性地影响 RV，导致明显的 RV 特异性临床表型。microRNAs 已被确定为驱动慢性疾病进展的生物学过程的关键调节因子。microRNAs 在影响左心室疾病中的作用已经研究了很多年，但是关于右心室疾病特异性 microRNAs 的信息仍然有限。在这里，我们综述了最近描述的关于 microRNAs 在右心病理性重构中的表达、调节和功能的细节。最近确定的将 microRNAs 作为药理学靶点或生物标志物的策略将被强调。对致病 microRNAs 的不断增加的认识最终将有助于提高我们对潜在的不同机制的理解，并有助于利用新的靶点或生物标志物来为患有右心疾病的患者开发治疗方法。
