Department of Microbiology, Konkuk University School of Medicine, Seoul, Republic of Korea.
Department of Pediatrics, Konkuk University Medical Center, Seoul, Republic of Korea.
Seizure. 2017 Nov;52:27-34. doi: 10.1016/j.seizure.2017.09.009. Epub 2017 Sep 15.
The association between iron deficiency anemia (IDA) and febrile seizures (FS) during childhood is inconclusive due to inconsistent results reported in different studies. We performed a systematic review and meta-analysis to determine an association between IDA and FS in children.
We searched PubMed, EMBASE, and Cochrane Library databases for studies published up to August 2015 using the following key words: ["iron deficiency" OR "iron status"] AND ["febrile seizure" OR "febrile convulsion"] AND ["pediatric" OR "infant" OR "child"]. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated using standard meta-analysis techniques. Subgroup analysis also was performed.
A total of 17 studies enrolling 2416 children with FS and 2387 controls were included in the meta-analysis. The results indicated that IDA was significantly associated with FS (OR, 1.98; 95% CI, 1.26-3.13; P=0.003). Subgroup analyses evaluated the diagnostic indices for IDA including serum iron, plasma ferritin, and mean corpuscular volume (MCV). The results indicated that IDA diagnosed on the basis of plasma ferritin (OR, 3.78; 95% CI, 1.80-7.94; P<0.001) or MCV (OR, 2.08; 95% CI, 1.36-3.17; P=0.001) was modestly associated with FS, whereas IDA diagnosed on the basis of two serum iron studies was not associated with FS (OR, 0.57; 95% CI, 0.24-1.37; P=0.210).
The results of this meta-analysis suggest that IDA is associated with an increased risk of FS in children.
由于不同研究结果不一致，铁缺乏性贫血（IDA）与儿童热性惊厥（FS）之间的关联尚无定论。我们进行了系统评价和荟萃分析，以确定儿童 IDA 与 FS 之间的关联。
我们使用以下关键词在 PubMed、EMBASE 和 Cochrane 图书馆数据库中搜索截至 2015 年 8 月发表的研究：["铁缺乏"或"铁状态"]和["热性惊厥"或"热性痉挛"]和["儿科"或"婴儿"或"儿童"]。使用标准荟萃分析技术计算合并优势比（OR）和 95%置信区间（CI）。还进行了亚组分析。
共有 17 项研究纳入了 2416 例 FS 患儿和 2387 例对照，进行了荟萃分析。结果表明，IDA 与 FS 显著相关（OR，1.98；95%CI，1.26-3.13；P=0.003）。亚组分析评估了 IDA 的诊断指标，包括血清铁、血浆铁蛋白和平均红细胞体积（MCV）。结果表明，基于血浆铁蛋白（OR，3.78；95%CI，1.80-7.94；P<0.001）或 MCV（OR，2.08；95%CI，1.36-3.17；P=0.001）诊断的 IDA 与 FS 中度相关，而基于两项血清铁研究诊断的 IDA 与 FS 无关（OR，0.57；95%CI，0.24-1.37；P=0.210）。
这项荟萃分析的结果表明，IDA 与儿童 FS 的风险增加有关。
