Sankar Haridev, Shriram Vanishree, Elayaraja Sivaprakasam
Department of General Surgery, Sri Ramachandra Institute of Higher Education and Research, Tamil Nadu, India.
Department of Community Medicine, Sri Ramachandra Institute of Higher Education and Research, Tamil Nadu, India.
J Family Med Prim Care. 2024 Dec;13(12):5562-5569. doi: 10.4103/jfmpc.jfmpc_520_24. Epub 2024 Dec 9.
This study looks into the relationship between febrile seizures in children between the ages of 6 months to 5 years who suffer from iron insufficiency. Febrile seizures, which are common in early life, are associated with abrupt temperature increases, and iron deficiency impacts neurological development in young infants. Understanding this relationship would lead to interventions that mitigate febrile seizure impact.
To investigate the link between iron deficiency and febrile seizures in children between the ages of 6 months and 5 years.
A "retrospective case-control study" of 300 cases and 300 controls, including demographic, seizure, and laboratory data, was conducted. Descriptive statistics were computed using "Chi-square tests for proportions" and "-tests for means" with ≤ 0.05 as the level of significance.
Significant findings emerged, including a notably younger mean age among cases (1.75 years) compared to controls (2.93 years). Cases showed higher rates of upper respiratory tract infections (3.7% vs. 0.3% in controls) and lower occurrences of viral febrile illnesses. Notably, cases had a lower prevalence of non-vegetarian diets and a higher incidence of family histories related to seizures. "Iron deficiency anemia" was more common in these instances, evident in blood parameters, alongside increased WBC counts. Recurrent seizures correlated with a lower mean RBC count ( = 0.01).
The study confirms the link between "iron deficiency anemia" and "febrile seizures" among young children. Addressing iron deficiency emerges as a critical modifiable factor in potentially reducing the occurrence and impact of severe seizures, emphasizing the necessity of proactive efforts in pediatric treatment programs.
本研究探讨6个月至5岁缺铁儿童的热性惊厥之间的关系。热性惊厥在儿童早期较为常见，与体温突然升高有关，而缺铁会影响幼儿的神经发育。了解这种关系将有助于采取干预措施减轻热性惊厥的影响。
调查6个月至5岁儿童缺铁与热性惊厥之间的联系。
进行了一项“回顾性病例对照研究”，包括300例病例和300例对照，收集了人口统计学、惊厥和实验室数据。使用“比例卡方检验”和“均值t检验”计算描述性统计量，显著性水平设定为p≤0.05。
出现了显著的研究结果，包括病例组的平均年龄（1.75岁）明显低于对照组（2.93岁）。病例组上呼吸道感染的发生率更高（3.7%，而对照组为0.3%），病毒性发热疾病的发生率更低。值得注意的是，病例组非素食饮食的患病率较低，有癫痫家族史的发生率较高。在这些病例中，“缺铁性贫血”更为常见，血液参数显示明显，同时白细胞计数增加。复发性惊厥与较低平均红细胞计数相关（p = 0.01）。
该研究证实了幼儿“缺铁性贫血”与“热性惊厥”之间的联系。解决缺铁问题成为潜在降低严重惊厥发生率和影响的关键可改变因素，强调了在儿科治疗方案中积极采取措施的必要性。
