Martin-Odoom Alexander, Adiku Theophilus, Delgado Elena, Lartey Margaret, Ampofo William K
Department of Medical Laboratory Sciences, School of Biomedical & Allied Health Sciences, College of Health Sciences, University of Ghana.
Department of Medical Microbiology, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana.
Ghana Med J. 2017 Mar;51(1):20-23. doi: 10.4314/gmj.v51i1.4.
Access to antiretroviral therapy in Ghana has been scaled up across the country over the last decade. This study sought to determine the occurrence of transmitted HIV-1 drug resistance in pregnant HIV-1 positive women yet to initiate antiretroviral therapy at selected HIV Care Centres in Ghana.
Plasma specimens from twenty-six (26) HIV seropositive pregnant women who were less than 28weeks pregnant with their first pregnancy and ART naïve were collected from selected HIV care centres in three (3) regions in Ghana. Genotypic testing was done for the reverse transcriptase gene and the sequences generated were analyzed for HIV-1 drug resistance mutations using the Stanford University HIV Drug Resistance Database.
Resistance mutations associated with the reverse transcriptase gene were detected in 4 (15.4%) of the participants. At least one major drug resistance mutation in the reverse transcriptase gene was found in 3 (11.5%) of the women.
The detection of transmitted HIV-1 drug resistance in this drug-naïve group in two regional HIV care sites is an indication of the need for renewed action in monitoring the emergence of transmitted HIV-1 drug resistance in Ghana.
None declared.
在过去十年中，加纳全国范围内抗逆转录病毒疗法的可及性得到了提升。本研究旨在确定在加纳选定的艾滋病护理中心，尚未开始接受抗逆转录病毒治疗的HIV-1阳性孕妇中传播性HIV-1耐药性的发生情况。
从加纳三个地区选定的艾滋病护理中心收集了26名HIV血清学阳性孕妇的血浆样本，这些孕妇处于首次怀孕且怀孕周数小于28周，并且未接受过抗逆转录病毒治疗。对逆转录酶基因进行基因分型检测，并使用斯坦福大学HIV耐药数据库对生成的序列进行HIV-1耐药性突变分析。
4名（15.4%）参与者检测到与逆转录酶基因相关的耐药性突变。3名（11.5%）女性在逆转录酶基因中发现至少一种主要耐药性突变。
在两个地区性艾滋病护理点的这个未接受过治疗的群体中检测到传播性HIV-1耐药性，表明需要重新采取行动监测加纳传播性HIV-1耐药性的出现情况。
无申报。
