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米源γ-谷维素对斯普拉格-道利大鼠的90天经口毒性研究。

Ninety-day oral toxicity study of rice-derived γ-oryzanol in Sprague-Dawley rats.

作者信息

Moon Seol-Hee, Kim Duyeol, Shimizu Norihito, Okada Tadashi, Hitoe Shoketsu, Shimoda Hiroshi

机构信息

Biotoxtech Co., Ltd., 53, Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, 363-883, Republic of Korea.

Oryza Oil & Fat Chemical Co. Ltd., 1 Numata, Kitagata-cho, Ichinomiya, Aichi 493-8001, Japan.

出版信息

Toxicol Rep. 2016 Dec 6;4:9-18. doi: 10.1016/j.toxrep.2016.12.001. eCollection 2017.

DOI:10.1016/j.toxrep.2016.12.001
PMID:28959620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5615091/
Abstract

A 90-day oral toxicity study of γ-oryzanol, a rice-derived triterpenoid ferulate, was performed by oral gavage administration to male and female Sprague-Dawley rats at doses of 0, 1000, and 2000 mg/kg body weight/day. All rats administered γ-oryzanol survived throughout the study period. Both male and female rats showed no toxicologically significant changes of the general signs, examination findings, body weight, food consumption, functional observational battery results, ophthalmological findings, urinalysis, hematology tests, clinical chemistry tests, organ weights, and necropsy findings. Moreover, there were no histopathological changes related to administration of γ-oryzanol in males and females from the 2000 mg/kg body weight/day group. In conclusion, the no observed adverse effect level (NOAEL) of γ-oryzanol exceeded 2000 mg/kg body weight/day for both male and female rats under the conditions of this study.

摘要

对雄性和雌性斯普拉格-道利大鼠经口灌胃给予不同剂量（0、1000和2000毫克/千克体重/天）的γ-谷维素（一种源自大米的三萜阿魏酸酯），进行了为期90天的口服毒性研究。所有给予γ-谷维素的大鼠在整个研究期间均存活。雄性和雌性大鼠在一般体征、检查结果、体重、食物摄入量、功能观察组合结果、眼科检查结果、尿液分析、血液学检测、临床化学检测、器官重量和尸检结果方面均未出现毒理学上的显著变化。此外，在2000毫克/千克体重/天组的雄性和雌性大鼠中，未发现与给予γ-谷维素相关的组织病理学变化。总之，在本研究条件下，γ-谷维素对雄性和雌性大鼠的无观察到有害作用水平（NOAEL）均超过2000毫克/千克体重/天。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1672/5615091/7011b2af085a/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1672/5615091/b25dab7f8d73/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1672/5615091/8463514833e6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1672/5615091/f8bb80016385/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1672/5615091/e8360ca90771/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1672/5615091/7011b2af085a/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1672/5615091/b25dab7f8d73/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1672/5615091/8463514833e6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1672/5615091/f8bb80016385/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1672/5615091/e8360ca90771/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1672/5615091/7011b2af085a/gr5.jpg

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