Docea Anca Oana, Vassilopoulou Loukia, Fragou Domniki, Arsene Andreea Letitia, Fenga Concettina, Kovatsi Leda, Petrakis Dimitrios, Rakitskii Valerii N, Nosyrev Alexander E, Izotov Boris N, Golokhvast Kirill S, Zakharenko Alexander M, Vakis Antonis, Tsitsimpikou Christina, Drakoulis Nikolaos
Department of Toxicology, University of Medicine and Pharmacy, Faculty of Pharmacy, 2 Petru Rares, 200349, Craiova, Romania.
Department of Toxicology and Forensic Sciences, Medical School, University of Crete, Heraklion, Greece.
Toxicol Rep. 2017 May 26;4:335-341. doi: 10.1016/j.toxrep.2017.05.007. eCollection 2017.
The association between genetic variations in the cytochrome P450 (CYP) family genes and pathological conditions related to long-term exposure to organochlorine compounds (OCs) deserves further elucidation. OCs are persistent organic pollutants with bioaccumulative and lipophilic characteristics. They can act as endocrine disruptors and perturb cellular mechanisms. Prolonged exposure to OCs has been associated with different pathological manifestations. CYP genes are responsible for transcribing enzymes essential in xenobiotic metabolism. Therefore, polymorphisms in these genetic sequences a. alter the metabolic pathways, b. induce false cellular responses, and c. may provoke pathological conditions. The main aim of this review is to define the interaction between parameters a, b and c at a mechanistic/molecular level, with references in clinical cases.
细胞色素P450（CYP）家族基因的遗传变异与长期接触有机氯化合物（OCs）相关的病理状况之间的关联值得进一步阐明。OCs是具有生物累积性和亲脂性特征的持久性有机污染物。它们可作为内分泌干扰物并扰乱细胞机制。长期接触OCs与不同的病理表现有关。CYP基因负责转录外源性物质代谢中必不可少的酶。因此，这些基因序列中的多态性：a. 改变代谢途径；b. 诱导错误的细胞反应；c. 可能引发病理状况。本综述的主要目的是在机制/分子水平上确定参数a、b和c之间的相互作用，并参考临床病例。
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