Strader C H, Weiss N S, Daling J R, Karagas M R, McKnight B
Hanford Environmental Health Foundation, Richland, WA.
Am J Epidemiol. 1988 May;127(5):1013-8. doi: 10.1093/oxfordjournals.aje.a114877.
Adult white male residents of 13 counties of western Washington State in whom germ cell testicular cancer was diagnosed between 1977 and 1983 (n = 333) were interviewed by telephone regarding their history of cryptorchism and its treatment. The same interview was given to a sample of 675 men selected from the population of these counties by dialing telephone numbers at random. Men who reported a history of cryptorchism were 5.9 times (95 per cent confidence interval 3.4-10.2) more likely than men without such a history to develop testicular cancer. Compared with noncryptorchid men, those with unilateral cryptorchism were at greater risk of developing a tumor on the side of nondescent (relative risk = 8.0) than on the opposite side (relative risk = 1.6). The size of the increased risk tended to be smaller among cryptorchid men who had undergone orchiopexy by age 10 than for other cryptorchid men, but the influence of orchiopexy in early childhood could not be evaluated in this population. These observations offer support for the hypothesis that one or more local factors (e.g., temperature elevation) account for the major part of the increased risk of germ cell testicular tumors in cryptorchid men.
对1977年至1983年间在华盛顿州西部13个县被诊断患有生殖细胞睾丸癌的成年白人男性居民（n = 333）进行了电话访谈，询问他们的隐睾病史及其治疗情况。通过随机拨打这些县的电话号码，对从这些县的人群中选取的675名男性样本进行了同样的访谈。报告有隐睾病史的男性患睾丸癌的可能性是没有这种病史的男性的5.9倍（95%置信区间3.4 - 10.2）。与非隐睾男性相比，单侧隐睾男性在未下降一侧发生肿瘤的风险（相对风险 = 8.0）高于对侧（相对风险 = 1.6）。在10岁前接受过睾丸固定术的隐睾男性中，风险增加的幅度往往比其他隐睾男性小，但在该人群中无法评估幼儿期睾丸固定术的影响。这些观察结果支持了这样一种假设，即一种或多种局部因素（如温度升高）是隐睾男性生殖细胞睾丸肿瘤风险增加的主要原因。
