负鼠弗吉尼亚负鼠红细胞能量代谢的研究——III. 2-脱氧葡萄糖导致的代谢耗竭显著加速负鼠而非人类红细胞中高铁血红蛋白的还原。
Studies on the energy metabolism of opossum Didelphis virginiana erythrocytes--III. Metabolic depletion with 2-deoxyglucose markedly accelerates methemoglobin reduction in opossum but not in human erythrocytes.
作者信息
Bethlenfalvay N C, Lima J E, Chadwick E, Stewart I
机构信息
Department of Primary Care, Fitzsimons Army Medical Center, Aurora, CO 80045-5000.
出版信息
Comp Biochem Physiol A Comp Physiol. 1988;89(2):119-24. doi: 10.1016/0300-9629(88)91067-5.
PMID:2896090
Abstract
- Glucose-depleted, nitrite-treated erythrocytes reduce ferriheme in vitro in an environment 100 mM to 2-deoxy-D-glucose at a rate of 2.4 microM/ml cells/hr (opossum) and 0.37 microM/ml cells/hr (human). 2. During the process of methemoglobin reduction the breakdown of adenine ribonucleotides is more rapid in opossum (0.9 microM/g hg/hr) than in human (0.36 microM/g hg/hr) erythrocytes. 3. Radiolabelled ribose from [U-14C] ATP is catabolized exclusively to [14C] lactate in opossum, and to [14C] pyruvate and [14C] lactate in human red cells.
摘要
- 葡萄糖耗尽、经亚硝酸盐处理的红细胞在含有100 mM 2-脱氧-D-葡萄糖的体外环境中，以2.4微摩尔/毫升细胞/小时（负鼠）和0.37微摩尔/毫升细胞/小时（人类）的速率还原高铁血红素。2. 在高铁血红蛋白还原过程中，负鼠红细胞（0.9微摩尔/克血红蛋白/小时）中腺嘌呤核糖核苷酸的分解比人类红细胞（0.36微摩尔/克血红蛋白/小时）更快。3. [U-14C]ATP中的放射性标记核糖在负鼠红细胞中仅分解为[14C]乳酸，而在人类红细胞中分解为[14C]丙酮酸和[14C]乳酸。
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