Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, Taiwan.
Mar Drugs. 2014 Feb 21;12(2):1148-56. doi: 10.3390/md12021148.
Three new eunicellin-type diterpenoids, krempfielins N-P (1-3), were isolated from a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compound 3 exhibited activity to inhibit superoxide anion generation. Both 1 and 3, in particular 1, were shown to display significant anti-inflammatory activity by inhibiting the elastase release in FMLP/CB-induced human neutrophils.
从台湾产软珊瑚 Cladiella krempfi 中分离得到 3 个新的海兔烯型二萜 krempfielin N-P（1-3）。通过广泛的光谱分析，并与相关已知化合物的光谱数据进行比较，确定了新代谢产物的结构。化合物 3 表现出抑制超氧阴离子生成的活性。1 和 3（特别是 1）均通过抑制 FMLP/CB 诱导的人中性粒细胞弹性蛋白酶释放显示出显著的抗炎活性。
