Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Mar Drugs. 2020 Apr 22;18(4):223. doi: 10.3390/md18040223.
Further chemical investigation of the EtOAc extract of the soft coral resulted in the discovery of eleven new diterpenoids lobovarols F-P (-) of lobane- and prenyleudesmane-types, along with two known metabolites ( and ). The structures of the new metabolites were established by spectroscopic analyses, including 2D NMR experiments. The absolute configuration of was determined using Mosher's method. The complete assignment of H and C NMR spectroscopic data of and and the identification of pyran-derived moieties in the prenyleudesmanes were reported for the first time. Anti-inflammatory activities of the isolated compounds in suppressing elastase release and superoxide anion generation in human neutrophils were disclosed for , , , , and . A stereospecific biosynthesis for lobanes and prenyleudesmanes from the related prenylgermacranes could explain the coexistence of lobanes and prenylgermacranes in .
从软珊瑚的 EtOAc 提取物中进一步的化学研究发现了 11 种新的二萜类化合物 lobovarols F-P（-），属于 lobane 和 prenyleudesmane 型，以及两种已知的代谢物（和）。新代谢物的结构通过光谱分析确定，包括 2D NMR 实验。使用 Mosher 法确定了的绝对构型。首次报道了和的 H 和 C NMR 光谱数据的完整分配以及 prenyleudesmanes 中吡喃衍生部分的鉴定。分离化合物在抑制人嗜中性粒细胞弹性蛋白酶释放和超氧阴离子生成方面的抗炎活性被披露，对于，，，，和。从相关的prenylgermacranes 立体特异性生物合成 lobanes 和 prenyleudesmanes 可以解释 lobanes 和 prenylgermacranes 在中的共存。
