Ma Junze, Liu Tao, Qu Jianqiang
Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China.
Department of Ophthalmology, The Central Hospital of Baoji City, Baoji, Shaanxi 721008, P.R. China.
Exp Ther Med. 2017 Sep;14(3):2211-2215. doi: 10.3892/etm.2017.4719. Epub 2017 Jul 7.
The aim of the study was to examine the effect of orbital implantation on peripheral blood melatonin and sex hormone levels in pediatric patients with congenital eyeball dysplasia. A total of 28 cases of pediatric patients with congenital eyeball dysplasia diagnosed in the Second Affiliated Hospital of Xi'an Jiaotong University from June 2014 to December 2014 were selected for the study. The patients included those that received orbital implantation, and the melatonin levels in the peripheral blood in patients before and after operation was observed. In addition, the sex hormone levels and T lymphocytes, plasma reactive oxygen species (ROS) and VEGF levels, urine 8-OHdG and 8-isoPGF2α levels in patients before and after treatment were detected, followed by statistical analysis. As a result, after 3 months of orbital implantation, the sex hormone levels in peripheral blood in child patients fluctuated significantly, and differences were not statistically significant (P>0.05). The peripheral blood T lymphocytes and ROS levels were significantly lower than those before treatment, and the differences were statistically significant (P<0.05). The correlation analysis revealed that the peripheral blood melatonin levels were negatively related to ROS levels; the correlation coefficient was rs = -0.481 and P<0.05. In conclusion, orbital implantation does not have significant impact on sex hormone levels in child patients with congenital eyeball dysplasia. The hydroxyapatite orbital implantation can achieve more satisfactory curative effects, and there are fewer postoperative complications. It does not affect the appearance of the eye, and therefore, it is suitable for patients with congenital eyeball dysplasia.
本研究旨在探讨眼眶植入术对先天性眼球发育不良患儿外周血褪黑素及性激素水平的影响。选取2014年6月至2014年12月在西安交通大学第二附属医院确诊的28例先天性眼球发育不良患儿作为研究对象。患者包括接受眼眶植入术者，观察其手术前后外周血中褪黑素水平。此外，检测患者治疗前后的性激素水平、T淋巴细胞、血浆活性氧（ROS）及血管内皮生长因子（VEGF）水平、尿8-羟基脱氧鸟苷（8-OHdG）及8-异前列腺素F2α（8-isoPGF2α）水平，随后进行统计学分析。结果显示，眼眶植入术后3个月，患儿外周血中性激素水平波动显著，但差异无统计学意义（P>0.05）。外周血T淋巴细胞及ROS水平显著低于治疗前，差异有统计学意义（P<0.05）。相关性分析显示，外周血褪黑素水平与ROS水平呈负相关；相关系数rs = -0.481，P<0.05。综上所述，眼眶植入术对先天性眼球发育不良患儿性激素水平无显著影响。羟基磷灰石眼眶植入术可取得更满意的疗效，术后并发症较少。不影响眼部外观，因此，适用于先天性眼球发育不良患者。
