Morgan Ashraf M, El-Ballal Salah S, El-Bialy Badre E, El-Borai Nermeen B
Toxicology and Forensic Medicine Department, Faculty of Veterinary Medicine, Cairo University, Egypt.
Pathology Department, Faculty of Veterinary Medicine, El-Sadat City University, Egypt.
Toxicol Rep. 2014 May 9;1:92-101. doi: 10.1016/j.toxrep.2014.04.003. eCollection 2014.
Among the numerous chemicals discharged into the surrounding environment, bisphenol A (BPA) and octylphenol (OP) have been shown to increase oxidative stress in body by disturbing the prooxidant/antioxidant balance of cells. Cinnamon aqueous extract (CAE) is a natural product rich in polyphenolic compounds that have antioxidant activity. This study was designed to investigate the protective efficacy of CAE against oxidative disorders induced by BPA and OP in male albino rats. Animals were divided into 6 groups (10 rats each) and treated orally, 3 times weekly for 50 days. Group 1: control vehicle (olive oil); group 2 (25 mg BPA/kg b.wt./day); group 3 (25 mg OP/kg b.wt./day); group 4 (200 mg CAE/kg b.wt./day); group 5 (CAE 2 h before BPA administration); and group 6 (CAE 2 h before OP administration). BPA- and OP-exposed groups showed insignificant elevation in the final body weight; weight gains and significant reduction only in the relative kidneys weight. Also, BPA and OP exposure resulted in significant increase in serum urea, creatinine and kidney, brain, testicular malondialdehyde (MDA) levels. Significant reduction in tissues reduced glutathione (GSH) contents; catalase (CAT) and superoxide dismutase (SOD) activities were also recorded in BPA and OP exposed animals compared to the control vehicle group. Pretreatment with CAE 2 h either before BPA or OP administration ameliorated the BPA- and OP-induced body weight; weight gains and relative organs weight changes and biochemical adverse effects. CAE pretreatment also protected against the recorded pathological changes in kidney, brain and testis. In conclusion, CAE could ameliorate the oxidative toxic effects of BPA and OP indicating its protective antioxidant effect.
在排放到周围环境中的众多化学物质中，双酚A（BPA）和辛基酚（OP）已被证明会通过扰乱细胞的促氧化剂/抗氧化剂平衡来增加体内的氧化应激。肉桂水提取物（CAE）是一种富含具有抗氧化活性的多酚类化合物的天然产物。本研究旨在探讨CAE对雄性白化大鼠中由BPA和OP诱导的氧化紊乱的保护作用。将动物分为6组（每组10只大鼠），每周口服给药3次，持续50天。第1组：对照载体（橄榄油）；第2组（25 mg BPA/千克体重/天）；第3组（25 mg OP/千克体重/天）；第4组（200 mg CAE/千克体重/天）；第5组（在给予BPA前2小时给予CAE）；第6组（在给予OP前2小时给予CAE）。暴露于BPA和OP的组在最终体重上显示出不显著的升高；体重增加，仅相对肾脏重量显著降低。此外，BPA和OP暴露导致血清尿素、肌酐以及肾脏、大脑、睾丸丙二醛（MDA）水平显著升高。与对照载体组相比，暴露于BPA和OP的动物组织中还原型谷胱甘肽（GSH）含量显著降低；过氧化氢酶（CAT）和超氧化物歧化酶（SOD）活性也有记录。在给予BPA或OP前2小时用CAE预处理改善了BPA和OP诱导的体重；体重增加以及相对器官重量变化和生化不良反应。CAE预处理还预防了在肾脏、大脑和睾丸中记录到的病理变化。总之，CAE可以改善BPA和OP的氧化毒性作用，表明其具有保护抗氧化作用。
