Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Department of Animal Science, Faculty of Agriculture, Federal University Dutse, Dutse, Jigawa State, Nigeria.
PLoS One. 2023 Aug 9;18(8):e0285090. doi: 10.1371/journal.pone.0285090. eCollection 2023.
Genetically modified (GM) crops expressing insecticidal crystal proteins are widely accepted worldwide, but their commercial utilization demands comprehensive risk assessment studies. A 90-day risk assessment study was conducted on Wistar rats fed with GM maize (CEMB-413) expressing binary insect-resistant genes (cry1Ac and cry2Ab) at low (30%) and high (50%) dose along with a control diet group. The study used fifty Wistar rats randomly distributed in five treatment groups. Our study revealed that compared to controls, GM diet had no adverse effects on animal's health, including body weight, food consumption, clinical pathological parameters, serum hormone levels and histological parameters of testes and ovaries of rats. Differences were observed in transcripts levels of fertility related genes, but these were independent of treatment with GM diet.
转基因为表达杀虫晶体蛋白的（GM）作物在全球范围内被广泛接受，但它们的商业利用需要进行全面的风险评估研究。一项为期 90 天的风险评估研究在 Wistar 大鼠身上进行，这些大鼠喂食表达二元抗虫基因（cry1Ac 和 cry2Ab）的 GM 玉米（CEMB-413），剂量分别为低（30%）和高（50%），同时还有一个对照组。研究使用了五十只 Wistar 大鼠，随机分配到五个处理组中。我们的研究表明，与对照组相比，GM 饮食对动物的健康没有不良影响，包括体重、食物消耗、临床病理参数、血清激素水平以及大鼠睾丸和卵巢的组织学参数。与 GM 饮食处理相关的生育相关基因的转录水平存在差异，但这些差异与 GM 饮食处理无关。
