Hammond B G, Dudek R, Lemen J K, Nemeth M A
Monsanto Company, Product Safety Center, 800 North Lindbergh Blvd., Bldg. O3F, St. Louis, MO 63167, USA.
Food Chem Toxicol. 2006 Jul;44(7):1092-9. doi: 10.1016/j.fct.2006.01.003. Epub 2006 Feb 17.
The results of a 90-day rat feeding study with grain from MON 810 corn (YieldGard Cornborer -- YieldGard Cornborer is a registered trademark of Monsanto Technology, LLC) that is protected against feeding damage from corn and stalk boring lepidopteran insects are presented. Corn borer protection was accomplished through the introduction of cry1Ab coding sequences into the corn genome for in planta production of a bioactive form of Cry1Ab protein. Grain from MON 810 and its near-isogenic control was separately formulated into rodent diets at levels of 11% and 33% (w/w) by Purina Mills, Inc. (PMI). All diets were nutritionally balanced and conformed to PMI specifications for Certified LabDiet (PMI Certified LabDiet 5002 is a registered trademark of Purina Mills, Inc.) 5002. There were a total of 400 rats in the study divided into 10 groups of 20 rats/sex/group. The responses of rats fed diets containing MON 810 were compared to those of rats fed grain from conventional corn varieties. Overall health, body weight, food consumption, clinical pathology parameters (hematology, blood chemistry, urinalysis), organ weights, and gross and microscopic appearance of tissues were comparable between groups fed diets containing MON 810 and conventional corn varieties. This study complements extensive agronomic, compositional and farm animal feeding studies with MON 810 grain, confirming that it is as safe and nutritious as grain from existing commercial corn varieties.
本文展示了一项对大鼠进行的为期90天的喂养研究结果，该研究使用了来自MON 810玉米（抗虫玉米——抗虫玉米是孟山都技术有限责任公司的注册商标）的谷物，这种玉米能抵御玉米螟和蛀茎鳞翅目昆虫的取食危害。通过将cry1Ab编码序列导入玉米基因组，使其在植物体内产生具有生物活性的Cry1Ab蛋白，从而实现了对玉米螟的抗性。孟山都公司的MON 810及其近等基因对照的谷物分别由普瑞纳磨坊公司（PMI）按照11%和33%（w/w）的水平配制成啮齿动物饲料。所有饲料在营养上都是均衡的，并且符合PMI认证实验动物饲料（PMI认证实验动物饲料5002是普瑞纳磨坊公司的注册商标）5002的规格。该研究共有400只大鼠，分为10组，每组20只大鼠（雌雄各半）。将喂食含MON 810饲料的大鼠的反应与喂食传统玉米品种谷物的大鼠的反应进行了比较。在喂食含MON 810饲料的组和喂食传统玉米品种饲料的组之间，大鼠的总体健康状况、体重、食物消耗量、临床病理参数（血液学、血液化学、尿液分析）、器官重量以及组织的大体和微观外观都是可比的。这项研究补充了对MON 810谷物进行的广泛的农艺学研究、成分分析研究和农场动物喂养研究，证实了它与现有商业玉米品种的谷物一样安全且营养丰富。
