McFadden J J, Butcher P D, Thompson J, Chiodini R, Hermon-Taylor J
Department of Surgery, St George's Hospital Medical School, London.
Mol Microbiol. 1987 Nov;1(3):283-91. doi: 10.1111/j.1365-2958.1987.tb01934.x.
DNA probes were used to identify restriction-fragment-length polymorphisms (RFLPs) in DNA samples, demonstrating that the Mycobacterium avium complex could be clearly divided into M. avium and Mycobacterium intracellulare strains. Less than 2% DNA base substitution was found between M. avium strains, whereas the M. intracellulare strains had greater than 15% base substitution. The Johne's disease bacillus, Mycobacterium paratuberculosis (American type strain), was found to be distinguishable from the M. avium complex serotypes examined. Strain 18 was found to be identical to M. avium. The rat leprosy bacillus, Mycobacterium lepraemurium, was found to be very closely related, but not identical, to M. avium.
DNA探针被用于识别DNA样本中的限制性片段长度多态性（RFLP），结果表明鸟分枝杆菌复合体可被明确分为鸟分枝杆菌和胞内分枝杆菌菌株。在鸟分枝杆菌菌株之间发现的DNA碱基替换不到2%，而胞内分枝杆菌菌株的碱基替换则超过15%。发现副结核分枝杆菌（美国标准菌株），即约内氏病杆菌，与所检测的鸟分枝杆菌复合体血清型有区别。发现18号菌株与鸟分枝杆菌相同。发现鼠麻风杆菌与鸟分枝杆菌非常密切相关，但并不相同。
