Hampson S J, Portaels F, Thompson J, Green E P, Moss M T, Hermon-Taylor J, McFadden J J
Department of Surgery, St George's Hospital Medical School, London.
Lancet. 1989 Jan 14;1(8629):65-8. doi: 10.1016/s0140-6736(89)91427-x.
Strains of the Mycobacterium avium intracellulare complex (MAIC) have become important colonisers of patients with acquired immunodeficiency syndrome (AIDS). Restriction fragment length polymorphisms were used to study the DNA from 88 MAIC isolates, including 51 derived from 47 AIDS patients. MAIC isolates from 33 of 45 AIDS patients were identical at the molecular level and distinct from the mycobacteria isolated from the stools of healthy subjects. The study also showed that serotyping correlates poorly with the genetic identity of these organisms. Mycobacterium paratuberculosis, which has been implicated in Crohn's disease, was not identified in any of the cultures studied.
鸟分枝杆菌胞内菌复合体（MAIC）菌株已成为获得性免疫缺陷综合征（AIDS）患者的重要定植菌。采用限制性片段长度多态性技术对88株MAIC分离株的DNA进行研究，其中51株来自47例AIDS患者。45例AIDS患者中33例的MAIC分离株在分子水平上是相同的，且与从健康受试者粪便中分离出的分枝杆菌不同。该研究还表明，血清分型与这些微生物的基因同一性相关性较差。在任何所研究的培养物中均未鉴定出与克罗恩病有关的副结核分枝杆菌。
