Soininen H, Riekkinen P J, Partanen J, Helkala E L, Laulumaa V, Jolkkonen J, Reinikainen K
Department of Clinical Neurology, Kuopio University Central Hospital, Finland.
Neurosci Lett. 1988 Feb 15;85(1):131-6. doi: 10.1016/0304-3940(88)90442-9.
Somatostatin levels of the cerebrospinal fluid (CSF) were correlated with variables of quantitative EEG and with neuropsychological performance in patients with probable Alzheimer's disease. Low somatostatin levels of CSF correlated with decreased beta activity and with decreased mean frequency in the combined alpha and theta EEG range. In the subgroup of mild Alzheimer cases CSF somatostatin correlated positively also with alpha power, and the peak and the mean frequency, and negatively with theta power but not with delta activity. Furthermore, low somatostatin of the CSF correlated with neuropsychological tests assessing temporoparietal dysfunction. To our knowledge, this is the first study to indicate the correlation between spectral analysis results of the EEG and CSF somatostatin suggesting that the relationship between somatostatin and EEG variables is worthy of further studies.
在可能患有阿尔茨海默病的患者中，脑脊液（CSF）中生长抑素水平与定量脑电图变量及神经心理表现相关。脑脊液中生长抑素水平低与β波活动减少以及α波和θ波脑电图范围内的平均频率降低相关。在轻度阿尔茨海默病病例亚组中，脑脊液生长抑素也与α波功率、峰值和平均频率呈正相关，与θ波功率呈负相关，但与δ波活动无关。此外，脑脊液中生长抑素水平低与评估颞顶叶功能障碍的神经心理测试相关。据我们所知，这是第一项表明脑电图频谱分析结果与脑脊液生长抑素之间存在相关性的研究，提示生长抑素与脑电图变量之间的关系值得进一步研究。
