Jelic V, Shigeta M, Julin P, Almkvist O, Winblad B, Wahlund L O
Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Stockholm, Sweden.
Dementia. 1996 Nov-Dec;7(6):314-23. doi: 10.1159/000106897.
In this study the best combination of quantitative electroencephalographic variables (qEEG) for the discrimination of groups with mild to moderate Alzheimer's disease (AD), mild cognitive impairment and healthy subjects was defined and related to neuropsychological performance. The study population included 18 patients with mild to moderate probable AD, 19 subjects with objective memory disturbance, 17 subjects with subjective memory complaints who did not have clinical evidence of memory disturbance, and 16 healthy controls. AD patients had significantly increased theta and decreased alpha relative power, mean frequency, and temporoparietal coherence. There was no significant difference in the mean frequency in the left temporal region between AD patients and subjects with objective memory disturbances. Temporoparietal coherence appeared as a discriminant variable together with alpha and theta relative power only between AD patients and controls giving 77.8% sensitivity and 100% specificity. Significant correlations between regional changes in qEEG variables and cognitive functions were found.
在本研究中，确定了用于区分轻度至中度阿尔茨海默病（AD）患者、轻度认知障碍患者和健康受试者的定量脑电图变量（qEEG）的最佳组合，并将其与神经心理学表现相关联。研究人群包括18例轻度至中度可能患有AD的患者、19例有客观记忆障碍的受试者、17例有主观记忆主诉但无记忆障碍临床证据的受试者以及16名健康对照者。AD患者的θ波相对功率显著增加，α波相对功率、平均频率和颞顶叶相干性降低。AD患者与有客观记忆障碍的受试者在左侧颞区的平均频率上无显著差异。颞顶叶相干性仅在AD患者与对照者之间作为判别变量出现，与α波和θ波相对功率一起，敏感性为77.8%，特异性为100%。发现qEEG变量的区域变化与认知功能之间存在显著相关性。
